Background aims Encouraging evidence of clinical benefits from cancer immunotherapy is
beginning to accumulate in several clinical trials. Cancer immunotherapy is based on two …

Adoptive cell transfer (ACT) of in vitro expanded autologous tumor-infiltrating lymphocytes
(TIL) has been shown to exert therapeutic efficacy in melanoma patients. We aimed to …

Purpose: Adoptive T-cell therapy is a promising strategy for the treatment of patients with
established tumors but is often limited to specific cancers where tumor-infiltrating …

Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune
response. In patients with malignancies, this approach is based on the possibility of …

Adoptive T cell therapy is a promising treatment strategy for patients with different types of
cancer. The methods used for generation of high numbers of tumor specific T cells usually …

Lessons learned over decades on the use of gene and cell therapies have found clinical
applicability in the field of cancer immunotherapy. On December 16th, 2016 a symposium …

Most cancer immunotherapies under present investigation are based on the belief that
cytotoxic T cells are the most important anti-tumoral immune cells, whereas intra-tumoral …

Purpose: A single vaccination of intact or reconstituted-lymphopenic mice (RLM) with a
granulocyte macrophage colony-stimulating factorsecreting B16BL6-D5 melanoma cell line …

Ex vivo–expanded tumor-infiltrating lymphocytes infused into lymphodepleted recipients has
clear antitumor efficacy. More practical sources of such antitumor lymphocytes would …

In this review, we tried to present the most recent findings concerning the use of T cells in
adoptive immunotherapy of malignant disease. Furthermore, we discuss some of the main …