Basal lamina changes in neurodegenerative disorders
Background Neurodegenerative disorders are a group of age-associated diseases
characterized by progressive degeneration of the structure and function of the CNS. Two key …
characterized by progressive degeneration of the structure and function of the CNS. Two key …
The vascular basement membrane in the healthy and pathological brain
MS Thomsen, LJ Routhe… - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The vascular basement membrane contributes to the integrity of the blood-brain barrier
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
(BBB), which is formed by brain capillary endothelial cells (BCECs). The BCECs receive …
Basement membrane and stroke
Y Yao - Journal of Cerebral Blood Flow & Metabolism, 2019 - journals.sagepub.com
Located at the interface of the circulation system and the CNS, the basement membrane
(BM) is well positioned to regulate blood–brain barrier (BBB) integrity. Given the important …
(BM) is well positioned to regulate blood–brain barrier (BBB) integrity. Given the important …
Blood-brain barrier dysfunction as a potential therapeutic target for neurodegenerative disorders
The blood-brain barrier (BBB) is composed of specific tight junction proteins and
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …
transporters expressed on the lining of endothelial cells of the vasculature in the brain. The …
The blood–brain barrier—A key player in multiple sclerosis disease mechanisms
TG Schreiner, C Romanescu, BO Popescu - Biomolecules, 2022 - mdpi.com
Over the past decade, multiple sclerosis (MS), a chronic neuroinflammatory disease with
severe personal and social consequences, has undergone a steady increase in incidence …
severe personal and social consequences, has undergone a steady increase in incidence …
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases
The cerebral vasculature serves as the crossroads of the CNS, supporting exchange of
nutrients, metabolic wastes, solutes and cells between the compartments of the brain …
nutrients, metabolic wastes, solutes and cells between the compartments of the brain …
Development, maintenance and disruption of the blood-brain barrier
B Obermeier, R Daneman, RM Ransohoff - Nature medicine, 2013 - nature.com
The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …
Blood-brain barrier dysfunction and the pathogenesis of Alzheimer's disease
Y Yamazaki, T Kanekiyo - International journal of molecular sciences, 2017 - mdpi.com
Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …
Age‐related ultrastructural changes of the basement membrane in the mouse blood‐brain barrier
LC Ceafalan, TE Fertig, TC Gheorghe… - Journal of cellular …, 2019 - Wiley Online Library
The blood‐brain barrier (BBB) is essential for a functional neurovascular unit. Most studies
focused on the cells forming the BBB, but very few studied the basement membrane (BM) of …
focused on the cells forming the BBB, but very few studied the basement membrane (BM) of …