Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum–plasma membrane junctions in mammalian brain neurons
M Kirmiz, NC Vierra, S Palacio… - Journal of …, 2018 - Soc Neuroscience
Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …
Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis
The association of plasma membrane (PM)-localized voltage-gated potassium (Kv2)
channels with endoplasmic reticulum (ER)-localized vesicle-associated membrane protein …
channels with endoplasmic reticulum (ER)-localized vesicle-associated membrane protein …
Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB
B Johnson, AN Leek, L Solé… - Proceedings of the …, 2018 - National Acad Sciences
Kv2. 1 exhibits two distinct forms of localization patterns on the neuronal plasma membrane:
One population is freely diffusive and regulates electrical activity via voltage-dependent K+ …
One population is freely diffusive and regulates electrical activity via voltage-dependent K+ …
Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling
NC Vierra, L Ribeiro-Silva, M Kirmiz… - Nature …, 2023 - nature.com
Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are
specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular …
specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular …
Activity-dependent endoplasmic reticulum Ca2+ uptake depends on Kv2.1-mediated endoplasmic reticulum/plasma membrane junctions to promote synaptic …
LC Panzera, B Johnson, JA Quinn… - Proceedings of the …, 2022 - National Acad Sciences
The endoplasmic reticulum (ER) forms a continuous and dynamic network throughout a
neuron, extending from dendrites to axon terminals, and axonal ER dysfunction is implicated …
neuron, extending from dendrites to axon terminals, and axonal ER dysfunction is implicated …
Kv2 channels create endoplasmic reticulum/plasma membrane junctions: a brief history of Kv2 channel subcellular localization
B Johnson, AN Leek, MM Tamkun - Channels, 2019 - Taylor & Francis
The potassium channels Kv2. 1 and Kv2. 2 are widely expressed throughout the mammalian
brain. Kv2. 1 provides the majority of delayed rectifying current in rat hippocampus while …
brain. Kv2. 1 provides the majority of delayed rectifying current in rat hippocampus while …
Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels
M Kirmiz, S Palacio, P Thapa, AN King… - Molecular biology of …, 2018 - Am Soc Cell Biol
The endoplasmic reticulum (ER) and plasma membrane (PM) form junctions crucial to ion
and lipid signaling and homeostasis. The Kv2. 1 ion channel is localized at ER–PM …
and lipid signaling and homeostasis. The Kv2. 1 ion channel is localized at ER–PM …
Induction of stable ER–plasma-membrane junctions by Kv2. 1 potassium channels
Junctions between cortical endoplasmic reticulum (cER) and the plasma membrane are a
subtle but ubiquitous feature in mammalian cells; however, very little is known about the …
subtle but ubiquitous feature in mammalian cells; however, very little is known about the …
The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K+ channels
C Marionneau, Y Carrasquillo, AJ Norris… - Journal of …, 2012 - Soc Neuroscience
The channel pore-forming α subunit Kv4. 2 is a major constituent of A-type (IA) potassium
currents and a key regulator of neuronal membrane excitability. Multiple mechanisms …
currents and a key regulator of neuronal membrane excitability. Multiple mechanisms …
Interdomain cytoplasmic interactions govern the intracellular trafficking, gating, and modulation of the Kv2. 1 channel
DP Mohapatra, DF Siino, JS Trimmer - Journal of Neuroscience, 2008 - Soc Neuroscience
Voltage-gated potassium (Kv) channels comprise four transmembrane α subunits, often
associated with cytoplasmic β subunits that impact channel expression and function. Here …
associated with cytoplasmic β subunits that impact channel expression and function. Here …
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