Computational modeling of corneal and scleral collagen photocrosslinking

BG Gerberich, AJ Wood-Yang, A Radmand… - Journal of Controlled …, 2022 - Elsevier
Scleral photocrosslinking is increasingly investigated for treatment of myopia and glaucoma.
In this study a computational model was developed to predict crosslinking efficiency of …

Photochemical kinetics model of corneal cross-linking with riboflavin

P Kamaev, M Smirnov, MD Friedman… - … & Visual Science, 2015 - iovs.arvojournals.org
Purpose: Corneal cross-linking (CXL) with riboflavin (Rf) for treatment of keratoconus has
been performed for many years. The underlying photochemical kinetic mechanisms have …

Iontophoresis-assisted accelerated riboflavin/ultraviolet A scleral cross-linking: a potential treatment for pathologic myopia

S Rong, C Wang, B Han, P Feng, W Lan, Z Gao… - Experimental Eye …, 2017 - Elsevier
Scleral collagen cross-linking is one of the most promising treatments to control the
pathologic process of myopia. However, the exact procedure and its impact on animal …

Illumination system for corneal collagen crosslinking

M Sheehan, B Watson… - Optometry and Vision …, 2011 - journals.lww.com
Purpose. We have designed and constructed an ultraviolet (UV) illumination system for use
in corneal collagen crosslinking (CXL) procedures. CXL is a recently developed procedure …

Computer modeling study of corneal cross-linking with riboflavin

R Pertaub, MD Friedman… - … & Visual Science, 2012 - iovs.arvojournals.org
Purpose:: To build a computational model of riboflavin (RF) diffusion and UVA absorption in
the cornea during corneal cross-linking to investigate differences between standard cross …

The effect of sodium iodide on stromal loading, distribution and degradation of riboflavin in a rabbit model of transepithelial corneal crosslinking

RS Rubinfeld, GG Gum, JH Talamo… - Clinical …, 2021 - Taylor & Francis
Purpose To evaluate effects of sodium iodide (NaI) on riboflavin concentration in corneal
stroma before and during ultraviolet A (UVA) light exposure using a novel transepithelial …

[HTML][HTML] Biomechanical Impact of Drug Formulation, Supplemental Oxygen, and UV Delivery on Epi-On CXL

DC Adler, J Hill, C Liu, P Deardorff… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Effective corneal crosslinking (CXL) requires sufficient photosensitizer, oxygen,
and UV in the stroma to induce free radical formation. Delivery of all three constituents is …

Corneal cross-linking: engineering a predictable model

RG Hepfer, C Shi, Y Wu… - Critical Reviews™ in …, 2014 - dl.begellhouse.com
Corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A (UVA) light has
become a viable treatment for keratoconus. In cases in which corneal transplant may have …

Photochemical Kinetic modeling for oxygen-enhanced UV-light-activated corneal collagen crosslinking

JT Lin - Ophthalmology Research: An International …, 2017 - geographical.go2journals.com
Aims: To derive analytic formulas for the efficacy of type-II corneal collagen crosslinking
(CXL) based on coupled macroscopic kinetic equations with an emphasis on the role of …

Optimization model for UV-riboflavin corneal cross-linking

S Schumacher, M Mrochen, J Wernli… - … & Visual Science, 2012 - iovs.arvojournals.org
Purpose.: To develop a theoretical model for riboflavin ultraviolet-A cross-linking treatment
that can predict the increase in stiffness of the corneal tissue as a function of the ultraviolet …