As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in
energy metabolism, maintenance of redox balance, and regulation of apoptosis …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

Mitochondria play a key role in cancer and their involvement is not limited to the production
of ATP only. Mitochondria also produce reactive oxygen species and building blocks to …

Mitochondria play pivotal roles in most eukaryotic cells, ranging from energy production to
regulation of apoptosis. As sites of cellular respiration, mitochondria experience …

Deregulated cellular energetics was one of the cancer hallmarks. Several underlying
mechanisms of deregulated cellular energetics are associated with mitochondrial …

Mitochondria are key regulators of cell survival and are involved in a plethora of
mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) …

Dysregulating cellular metabolism is one of the emerging cancer hallmarks. Mitochondria
are essential organelles responsible for numerous physiologic processes, such as energy …

Mitochondrial processes play an important role in tumor initiation and progression. In this
review, we focus on three critical processes by which mitochondrial function may contribute …

Nearly a century of scientific research has revealed a number of notable differences in the
structure and function of mitochondria between normal and cancer cells, including …

Cancer is a heterogeneous set of diseases characterized by different molecular and cellular
features. Over the past decades, researchers have attempted to grasp the complexity of …