While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

An experimental paradigm for the study of mechanisms of resistance to aging in long-lived
organisms has been developed. The paradigm assumes, in concert with accumulating …

Hardly an aspect of aging is more important than an organism's ability to withstand stress or
to resist both internally and externally imposed insults. We know that as organisms loose …

Mutations in genes affecting endocrine signaling, stress responses, metabolism, and
telomeres can all increase the life spans of model organisms. These mutations have …

Ageing is driven by the inexorable and stochastic accumulation of damage in biomolecules
vital for proper cellular function. Although this process is fundamentally haphazard and …

In this work, we examine the relationship between stress resistance and aging. We find that
resistance to multiple types of stress peaks during early adulthood and then declines with …

Aging can be defined as the progressive decline in tissue and organismal function and the
ability to respond to stress that occurs in association with homeostatic failure and the …

Ageing is defined by the loss of functional reserve over time, leading to a decreased
capacity to maintain homeostasis under stress and increased risk of morbidity and mortality …

Survival to old age is enhanced by high vitality and resilience associated with substantial
physiological and morphological homeostasis. This is underlain by genes for stress …

Work, initially in Caenorhabditis elegans and then more recently in fruit flies and mice, has
suggested that anti-aging mutations extend life span by simultaneous activation of pathways …