Tumor cells recruit vascular endothelial cells and circulating endothelial progenitor cells to
form new vessels to support their own growth and metastasis. VEGF, PDGF-BB and FGF-2 …

Angiogenesis has an essential role in tumor growth and metastasis, and blocking this
pathway has been a successfully utilized strategy in the clinical treatment of cancer …

Abrogating tumor angiogenesis by inhibiting vascular endothelial growth factor receptor‐2
(VEGFR 2) has been established as a therapeutic strategy for treating cancer. However …

Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents, with highly aggressive behavior and early systemic metastasis. The survival …

Angiogenesis is an important process in cell development, especially in cancer. Vascular
endothelial growth factor (VEGF) signaling is an important regulator of angiogenesis …

Background Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs)
targeting vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor …

Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

The shaping of new blood vessels is a significant event in cancer growth and metastasis.
Therefore, the molecular system of cancer angiogenesis has garnered considerable interest …

A vast amount of data shows that angiogenesis has a pivotal role in tumor growth,
progression, invasiveness and metastasis. This is a complex process involving essential …

Objective: Lymphatic metastasis is one of the leading causes of malignancy dispersion in
various types of cancer. However, few anti-lymphangiogenic drugs have been approved for …