Silica nanoparticles inhibit macrophage activity and angiogenesis via VEGFR2-mediated MAPK signaling pathway in zebrafish embryos

J Duan, H Hu, L Feng, X Yang, Z Sun - Chemosphere, 2017 - Elsevier
The safety evaluation of silica nanoparticles (SiNPs) are getting great attention due to its
widely-used in food sciences, chemical industry and biomedicine. However, the adverse …

Inflammation–coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos

J Duan, S Liang, Y Yu, Y Li, L Wang, Z Wu… - …, 2018 - Taylor & Francis
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining
attention. We previously found that silica nanoparticles (SiNPs) could induce vascular …

Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos

J Duan, Y Yu, Y Li, Y Li, H Liu, L Jing, M Yang… - …, 2016 - Taylor & Francis
The toxicity mechanism of nanoparticles on vertebrate cardiovascular system is still unclear,
especially on the low-level exposure. This study was to explore the toxic effect and …

Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model

J Duan, Y Yu, Y Li, Y Yu, Z Sun - Biomaterials, 2013 - Elsevier
Environmental exposure to nanomaterials is inevitable as nanomaterials become part of our
daily life, and as a result, nanotoxicity research is gaining attention. However, most …

Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling

C Guo, Y Xia, P Niu, L Jiang, J Duan, Y Yu… - International journal …, 2015 - Taylor & Francis
Despite the widespread application of silica nanoparticles (SiNPs) in industrial, commercial,
and biomedical fields, their response to human cells has not been fully elucidated. Overall …

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway

L Feng, X Yang, S Liang, Q Xu, MR Miller… - Particle and fibre …, 2019 - Springer
Background Safety evaluation is a prerequisite for nanomaterials in a wide range of fields,
including chemical industries, medicine or food sciences. Previously, we had demonstrated …

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

J Duan, S Liang, L Feng, Y Yu, Z Sun - International Journal of …, 2018 - Taylor & Francis
Background As a promising nanocarrier in biomedical fields, silica nanoparticles (SiNPs)
could transfer from the circulatory system to multiple organs. Among these, blood–liver …

Toxic effects of silica nanoparticles on zebrafish embryos and larvae

J Duan, Y Yu, H Shi, L Tian, C Guo, P Huang, X Zhou… - PloS one, 2013 - journals.plos.org
Silica nanoparticles (SiNPs) have been widely used in biomedical and biotechnological
applications. Environmental exposure to nanomaterials is inevitable as they become part of …

Inflammatory response and blood hypercoagulable state induced by low level co-exposure with silica nanoparticles and benzo [a] pyrene in zebrafish (Danio rerio) …

J Duan, Y Yu, Y Li, Y Wang, Z Sun - Chemosphere, 2016 - Elsevier
Given the severe situation of world-wide particulate matter air pollution, it is urgent to explore
the combined effects of particulate matter components on cardiovascular system. Using …

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos

H Hu, Q Li, L Jiang, Y Zou, J Duan… - Toxicology Research, 2016 - academic.oup.com
Although silica nanoparticles (SiNPs) have a promising application in biomedical fields,
there is still a lack of comprehensive understanding of genome-wide transcriptional analysis …