In Silico Identification and Validation of Pyroptosis-Related Genes in Chlamydia Respiratory Infection

R Sun, W Zheng, S Yang, J Zeng, Y Tuo, L Tan… - International Journal of …, 2023 - mdpi.com
The incidence of Chlamydia trachomatis respiratory infection is increasing, and its
pathogenesis is still unclear. Pyroptosis, as a mode of inflammatory cell death, plays a vital …

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

P Jiang, H Chen, X Feng, H Xie, M Jiang… - Frontiers in Cellular …, 2023 - frontiersin.org
Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense
mechanism against microbial infections. Although Chlamydia has been shown to induce …

LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent Chlamydia trachomatis infection

F Luo, Y Wen, L Zhao, S Su, W Lei, L Chen, C Chen… - Virulence, 2022 - Taylor & Francis
Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating
sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent …

Identification of the role of pyroptosis-related genes in chronic rhinosinusitis based on WGCNA

Y Wan, Y Wang, S Xu, H Du, Z Liu - Heliyon, 2024 - cell.com
Background Chronic rhinosinusitis (CRS) is a complex chronic inflammatory disease of the
nose, paranasal sinus, and upper respiratory tract. Its treatment methods mainly include …

Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development

F Luo, Y Wen, L Zhao, S Su, Y Zhao… - Journal of cellular and …, 2022 - Wiley Online Library
Chlamydia trachomatis persistent infection is the leading cause of male prostatitis and
female genital tract diseases. Inhibition of host cell apoptosis is the key to maintaining …

A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma

W Zhu, Z Ye, L Chen, H Liang, Q Cai - International immunopharmacology, 2021 - Elsevier
Background Pyroptosis, a type of regulated cell death controlled by the gasdermin family of
proteins to form plasma membrane pores is known. Nonetheless, the function of pyroptosis …

Pyroptosis‐Related Gene Signature Predicts the Prognosis of ccRCC Using TCGA and Single‐Cell RNA Seq Database

Y Gan, Z Zhang, X Wang, A Li, Y Fan… - Journal of Healthcare …, 2022 - Wiley Online Library
Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of renal carcinoma, which
is not sensitive to both radiotherapy and chemotherapy. The objective response rate of …

[HTML][HTML] A novel pyroptosis-related gene signature for predicting laryngeal carcinoma prognosis

H Zhang, L Wang, Z Yin, L Ji, Y Guo - International Journal of …, 2022 - ncbi.nlm.nih.gov
Pyroptosis, a newly-defined mode of cell death related to inflammation, is closely related to
cancers but has not yet been studied in laryngeal carcinoma (LC). We investigated …

Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis

L Wang, J Zhang, L Zhang, L Hu, J Tian - Frontiers in Cellular and …, 2022 - frontiersin.org
Background Sepsis is regarded as a life-threatening organ dysfunction syndrome that
responds to infection. Pyroptosis, a unique form of programmed cell death, is characterized …

Chlamydia trachomatis upregulates lncRNA CYTOR to mediate autophagy through miR-206/MAPK1 axis

S Cheng, Y Liu, B He, J Zhang, Y Yang… - Pathogens and …, 2024 - academic.oup.com
Chlamydia trachomatis infection can be regulated by autophagy-related genes. LncRNA
CYTOR has been proven to be involved in autophagy. In this research, we investigated the …