[HTML][HTML] Neuropeptide Y is an immunomodulatory factor: direct and indirect

W Chen, Y Liu, W Liu, Y Zhou, H He, S Lin - Frontiers in immunology, 2020 - frontiersin.org
Neuropeptide Y (NPY), which is widely distributed in the nervous system, is involved in
regulating a variety of biological processes, including food intake, energy metabolism, and …

The intriguing mission of neuropeptide Y in the immune system

M Dimitrijević, S Stanojević - Amino acids, 2013 - Springer
For many years, the central nervous system and the immune system were considered two
autonomous entities. However, extensive research in the field of neuroimmunomodulation …

A role for neuropeptide Y (NPY) in phagocytosis: implications for innate and adaptive immunity

S Bedoui, S von Hörsten, T Gebhardt - Peptides, 2007 - Elsevier
Although it is broadly accepted that the immune system and the nervous system functionally
interact with each other at various levels, many aspects of this crosstalk still remain unclear …

The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour

A Farzi, F Reichmann, P Holzer - Acta Physiologica, 2015 - Wiley Online Library
Neuropeptide Y (NPY), one of the most abundant peptides in the nervous system, exerts its
effects via five receptor types, termed Y 1, Y 2, Y 4, Y 5 and Y 6. NPY's pleiotropic functions …

NPY and receptors in immune and inflammatory diseases

J Wheway, H Herzog, F Mackay - Current topics in medicinal …, 2007 - ingentaconnect.com
Growing evidence suggests that neuropeptide Y (NPY) plays an important role in the
immune system. NPY is produced by the central and peripheral nervous system but also by …

[HTML][HTML] Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: A review

Y Zhang, CY Liu, WC Chen, YC Shi, CM Wang, S Lin… - Cell & Bioscience, 2021 - Springer
Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely
expressed in the central and peripheral nervous systems and acts on the cardiovascular …

[HTML][HTML] Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation

K Singer, DL Morris, KE Oatmen, T Wang… - PloS one, 2013 - journals.plos.org
Neuropeptide Y (NPY) is induced in peripheral tissues such as adipose tissue with obesity.
The mechanism and function of NPY induction in fat are unclear. Given the evidence that …

[HTML][HTML] Neuron-derived neuropeptide Y fine-tunes the splenic immune responses

J Yu, K Xiao, X Chen, L Deng, L Zhang, Y Li, A Gao… - Neuron, 2022 - cell.com
The nervous and immune systems are closely entwined to maintain the immune balance in
health and disease. Here, we showed that LPS can activate suprarenal and celiac ganglia …

The Y1 receptor for NPY: a key modulator of the adaptive immune system

J Wheway, H Herzog, F Mackay - Peptides, 2007 - Elsevier
Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in
the immune system. Yet, little is known about the expression of NPY and receptors in the …

Relevance of neuropeptide Y for the neuroimmune crosstalk

S Bedoui, N Kawamura, RH Straub, R Pabst… - Journal of …, 2003 - Elsevier
Both cellular and humoral functions of the immune system are modulated by the sympathetic
nervous system (SNS). This interaction is mainly mediated by the release of catecholamines …