Topography-mediated immunomodulation in osseointegration; Ally or Enemy

S Shirazi, S Ravindran, LF Cooper - Biomaterials, 2022 - Elsevier
Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

[HTML][HTML] Osteoimmune regulation underlies oral implant osseointegration and its perturbation

T Albrektsson, P Tengvall, L Amengual, P Coli… - Frontiers in …, 2023 - frontiersin.org
In the field of biomaterials, an endosseous implant is now recognized as an
osteoimmunomodulatory but not bioinert biomaterial. Scientific advances in bone cell …

[HTML][HTML] Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis

J Li, C Zhao, Y Xu, L Song, Y Chen, Y Xu, Y Ma… - Bioactive materials, 2023 - Elsevier
Osseointegration seems to be a foreign body reaction equilibrium due to the complicated
interactions between the immune and skeletal systems. The heterogeneity of the …

Osteoinduction and osteoimmunology: Emerging concepts

RJ Miron, M Bohner, Y Zhang… - Periodontology …, 2024 - Wiley Online Library
The recognition and importance of immune cells during bone regeneration, including
around bone biomaterials, has led to the development of an entire field termed …

A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration

L Bai, Z Du, J Du, W Yao, J Zhang, Z Weng, S Liu… - Biomaterials, 2018 - Elsevier
A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis,
and osteoimmunomodulation abilities, would be of great value since it could improve …

[HTML][HTML] Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry

L Amengual-Penafiel, LA Córdova… - … Dental Science Review, 2021 - Elsevier
There is a complex interaction between titanium dental implants, bone, and the immune
system. Among them, specific immune cells, macrophages play a crucial role in the …

[HTML][HTML] Chronic implant-related bone infections—can immune modulation be a therapeutic strategy?

E Seebach, KF Kubatzky - Frontiers in immunology, 2019 - frontiersin.org
Chronic implant-related bone infections are a major problem in orthopedic and trauma-
related surgery with severe consequences for the affected patients. As antibiotic resistance …

Immunomodulatory strategies for bone regeneration: a review from the perspective of disease types

N Su, C Villicana, F Yang - Biomaterials, 2022 - Elsevier
Tissue engineering strategies for treating bone loss to date have largely focused on
targeting stem cells or vascularization. Immune cells, including macrophages and T cells …

[HTML][HTML] Immunomodulation effect of biomaterials on bone formation

T Zhao, Z Chu, J Ma, L Ouyang - Journal of Functional Biomaterials, 2022 - mdpi.com
Traditional bone replacement materials have been developed with the goal of directing the
osteogenesis of osteoblastic cell lines toward differentiation and therefore achieving …

Regulation of macrophage polarization by mineralized collagen coating to accelerate the osteogenic differentiation of mesenchymal stem cells

J Shao, L Weng, J Li, H Lin, H Wang… - … Biomaterials Science & …, 2022 - ACS Publications
Osteogenesis on the interface between the implant and host bone is a synergistic
processing of multiple systems involved in immune response, angiogenesis, osteogenesis …