Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

LQ Zhu, SH Wang, D Liu, YY Yin, Q Tian… - Journal of …, 2007 - Soc Neuroscience
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …

Glycogen synthase kinase‐3 inhibition is integral to long‐term potentiation

C Hooper, V Markevich, F Plattner… - European journal of …, 2007 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating
diverse cellular functions including metabolism, transcription and cell survival. Numerous …

[HTML][HTML] LTP inhibits LTD in the hippocampus via regulation of GSK3β

S Peineau, C Taghibiglou, C Bradley, TP Wong, L Liu… - Neuron, 2007 - cell.com
Summary Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological
disorders, but its role in normal neuronal function is largely unknown. Here we show that …

Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced …

E Rockenstein, M Torrance, A Adame… - Journal of …, 2007 - Soc Neuroscience
The glycogen synthase kinase-3β (GSK3β) pathway plays an important role in mediating
neuronal fate and synaptic plasticity. In Alzheimer's disease (AD), abnormal activation of this …

β-Amyloid impairs the regulation of N-methyl-D-aspartate receptors by glycogen synthase kinase 3

Y Deng, Z Xiong, P Chen, J Wei, S Chen, Z Yan - Neurobiology of aging, 2014 - Elsevier
Accumulating evidence suggests that glycogen synthase kinase 3 (GSK-3) is a
multifunctional kinase implicated in Alzheimer's disease (AD). However, the synaptic actions …

GSK‐3: A key player in neurodegeneration and memory

KP Giese - IUBMB life, 2009 - Wiley Online Library
Abnormalities in molecular signalling have been implicated in neurodegeneration. It is
emerging that glycogen synthase kinase‐3 (GSK‐3) is a key signalling molecule that …

[HTML][HTML] A pivotal role of GSK-3 in synaptic plasticity

CA Bradley, S Peineau, C Taghibiglou… - Frontiers in molecular …, 2012 - frontiersin.org
Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence
suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of …

The role of GSK‐3 in synaptic plasticity

S Peineau, C Bradley, C Taghibiglou… - British journal of …, 2008 - Wiley Online Library
Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism
pathway, is highly expressed in the CNS. It has been implicated in major neurological …

Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3

T Engel, F Hernández, J Avila… - Journal of Neuroscience, 2006 - Soc Neuroscience
Glycogen synthase kinase-3 (GSK-3) is a ubiquitously expressed serine/threonine kinase
that is particularly abundant in the CNS. Dysregulation of GSK-3 activity is believed to play a …

GSK-3β inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting snare complex formation

LQ Zhu, D Liu, J Hu, J Cheng, SH Wang… - Journal of …, 2010 - Soc Neuroscience
Glycogen synthase kinase-3 (GSK-3), a Ser/Thr protein kinase abundantly expressed in
neurons, plays diverse functions in physiological and neurodegenerative conditions. Our …