Elucidation of the Genomic‐Epigenomic Interaction Landscape of Aggressive Prostate Cancer

TK Kumar Mamidi, J Wu, C Hicks - BioMed research …, 2021 - Wiley Online Library
Background. Majority of prostate cancer (PCa) deaths are attributed to localized high‐grade
aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in …

Interactions between germline and somatic mutated genes in aggressive prostate cancer

TKK Mamidi, J Wu, C Hicks - Prostate Cancer, 2019 - Wiley Online Library
Prostate cancer (PCa) is the most common diagnosed malignancy and the second leading
cause of cancer‐related deaths among men in the USA. Advances in high‐throughput …

Mapping the germline and somatic mutation interaction landscape in indolent and aggressive prostate cancers

TKK Mamidi, J Wu, C Hicks - Journal of Oncology, 2019 - Wiley Online Library
Background. A majority of prostate cancers (PCas) are indolent and cause no harm even
without treatment. However, a significant proportion of patients with PCa have aggressive …

An Integrative analysis of chromatin interactions, gene expression and genomic variants identifies 30 likely regulatory variants in Prostate Cancer

M Labani, A Beheshti, A Argha, H Alinejad - 2023 - preprints.org
Prostate cancer (PC) is the most frequently diagnosed non-skin cancer in the world.
Previous studies showed that genomic alterations represent the most common mechanism …

Multi-omic profiling of prostate cancer evolution in 39 patients

Q Zhong, T Guo, N Toussaint, U Wagner, K Charmpi… - Cancer Research, 2017 - AACR
The pathological molecular events occurring during prostate cancer (PCa) progression have
not been comprehensively investigated. It remains elusive how genomic aberration is …

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

TKK Mamidi, J Wu, C Hicks - BMC cancer, 2019 - Springer
Abstract Background Prostate cancer (PCa) is the most common diagnosed malignancy and
the second leading cause of cancer-related deaths among men in the United States. High …

Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression

S Ren, GH Wei, D Liu, L Wang, Y Hou, S Zhu, L Peng… - European urology, 2018 - Elsevier
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …

Integrative multi-omics analysis enables a comprehensive characterization of prostate cancer and unveils metastasis-associated candidate biomarkers

M Villa, G Cazzaniga, M Bolognesi, V Crippa… - Cancer Research, 2024 - AACR
Prostate cancer (PCa), a common malignancy in men, presents a complex and variable
disease landscape, requiring precise evaluation for personalized treatment decisions …

Genomic, epigenomic, and transcriptomic signatures of prostate cancer between African American and European American patients

C Stevens, A Hightower, SG Buxbaum… - Frontiers in …, 2023 - frontiersin.org
Prostate cancer is the second most common cancer in men in the United States, and racial
disparities are greatly observed in the disease. Specifically, African American (AA) patients …

From omics to multi-omics approaches for in-depth analysis of the molecular mechanisms of prostate cancer

E Nevedomskaya, B Haendler - International Journal of Molecular …, 2022 - mdpi.com
Cancer arises following alterations at different cellular levels, including genetic and
epigenetic modifications, transcription and translation dysregulation, as well as metabolic …