Experimental gentamicin nephrotoxicity and agents that modify it: a mini‐review of recent research

BH Ali, M Al Za'abi, G Blunden… - Basic & clinical …, 2011 - Wiley Online Library
The aminoglycoside antibiotic gentamicin (GM) is still widely used against infections by
Gram‐positive and Gram‐negative aerobic bacteria. Its therapeutic efficacy, however, is …

Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?

P Balakumar, A Rohilla, A Thangathirupathi - Pharmacological research, 2010 - Elsevier
Aminoglycoside antibiotics are employed clinically because of their potent bactericidal
activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs …

[HTML][HTML] New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view

JM Lopez-Novoa, Y Quiros, L Vicente, AI Morales… - Kidney international, 2011 - Elsevier
Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research

BH Ali - Food and Chemical Toxicology, 2003 - Elsevier
Despite its nephrotoxic potential, the aminoglycoside antibiotic gentamicin (GM) is still
considered to be an important agent against life-threatening infections. The goal of reducing …

[HTML][HTML] Gentamicin nephrotoxicity in animals: Current knowledge and future perspectives

P Randjelovic, S Veljkovic, N Stojiljkovic… - EXCLI …, 2017 - ncbi.nlm.nih.gov
Due to high relative blood flow the kidney is prone to drug-induced damage.
Aminoglycoside type antibiotic gentamicin is one of the leading cause of drug-induced …

An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin

Y Quiros, L Vicente-Vicente, AI Morales… - Toxicological …, 2011 - academic.oup.com
Gentamicin is an aminoglycoside antibiotic widely used against infections by Gram-negative
microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy. Gentamicin …

Gentamicin nephrotoxicity in humans and animals: some recent research

BH Ali - General Pharmacology: The Vascular System, 1995 - Elsevier
Gentamicin is an aminoglycoside antibiotic that is still commonly used in the treatment of life-
threatening infections. Their broad-spectrum activity against aerobic gram+ ve and gram-ve …

Protective effects of pharmacological agents against aminoglycoside-induced nephrotoxicity: A systematic review

M Mahi-Birjand, S Yaghoubi… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Aminoglycosides have been long used for antibacterial treatment and are still
commonly used in clinical practice. Despite their extensive application and positive effects …

Glomerular nephrotoxicity of aminoglycosides

C Martinez-Salgado, FJ López-Hernández… - Toxicology and applied …, 2007 - Elsevier
Aminoglycoside antibiotics are the most commonly used antibiotics worldwide in the
treatment of Gram-negative bacterial infections. However, aminoglycosides induce …

A prospective comparative study of gentamicin‐and amikacin‐induced nephrotoxicity in patients with normal baseline renal function

WM Sweileh - Fundamental & clinical pharmacology, 2009 - Wiley Online Library
The aim of this study was to compare the nephrotoxic potential of amikacin (AK) and
gentamicin (GM) in patients with normal baseline renal function. This study was a 1‐year …