The pathogenesis of type 2 diabetes is intimately intertwined with the vasculature. Insulin
must efficiently enter the bloodstream from pancreatic β-cells, circulate throughout the body …

Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Pericytes are mural cells that support and stabilise the microvasculature, and are present in
all vascular beds. Pericyte-endothelial cell crosstalk is essential in both remodelling and …

The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and
deliver insulin and glucagon into the circulation. Long believed to be passive conduits of …

Background Insulin has been demonstrated to exert direct and indirect effects on vascular
tissues. Its actions in vascular cells are mediated by two major pathways: the insulin receptor …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

Pancreatic islets are endocrine organs that depend on their microvasculature to function.
Along with endothelial cells, pericytes comprise the islet microvascular network. These …

β-Cells rely on the islet microenvironment for their functionality and mass. Pericytes, along
with endothelial cells, make up the dense islet capillary network. However, although the role …

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-
cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response …