The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut
surface to multiple environmental antigens and to billions of microbes have been scrutinized …

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic or relapsing immune activation and corresponding inflammation within the …

Inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease are
chronic and relapsing conditions, characterized by abdominal pain, diarrhea, bleeding and …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the
intestines that is clinically heterogenous. The cause (s) of IBD are currently unknown but the …

The intestine and its immune system have evolved to meet the extraordinary task of
maintaining tolerance to the largest, most complex and diverse microbial commensal …

IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main
clinical entities: Crohn's disease and ulcerative colitis. Although Crohn's disease and …

The uncontrolled activation of the immune system toward antigens contained in the gut
lumen in genetically predisposed subjects is believed to be the leading cause of …

The gastrointestinal tract is the largest immune interface with the environment. Exposure to
large numbers of dietary and microbial antigens requires complex and highly regulated …

The etiology of human inflammatory bowel diseases (IBDs) is believed to involve
inappropriate host responses to the complex commensal microbial flora in the gut, although …