Termination of non-coding transcription in yeast relies on both a CTD-interaction domain and a CTD-mimic in Sen1
Z Han, O Jasnovidova, A Tudek, K Kubicek, D Libri… - bioRxiv, 2018 - biorxiv.org
Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non-coding RNAs (ncRNAs) without apparent function. Pervasive transcription poses a …
of non-coding RNAs (ncRNAs) without apparent function. Pervasive transcription poses a …
Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1
Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …
Modulated termination of non-coding transcription partakes in the regulation of gene expression
N Haidara, M Giannini, O Porrua - Nucleic Acids Research, 2022 - academic.oup.com
Pervasive transcription is a universal phenomenon leading to the production of a plethora of
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …
Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination
Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …
A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast
O Porrua, D Libri - Nature structural & molecular biology, 2013 - nature.com
Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …
[HTML][HTML] Cell-cycle modulation of transcription termination factor Sen1
Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …
[HTML][HTML] Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome
Transcriptome studies on eukaryotic cells have revealed an unexpected abundance and
diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which …
diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which …
[HTML][HTML] Single-molecule reconstruction of eukaryotic factor-dependent transcription termination
Y Xiong, W Han, C Xu, J Shi, L Wang, T Jin… - Nature …, 2024 - nature.com
Factor-dependent termination uses molecular motors to remodel transcription machineries,
but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we …
but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we …
[HTML][HTML] RNA polymerase II CTD tyrosine 1 is required for efficient termination by the Nrd1-Nab3-Sen1 pathway
In Saccharomyces cerevisiae, transcription termination at protein-coding genes is coupled to
the cleavage of the nascent transcript, whereas most non-coding RNA transcription relies on …
the cleavage of the nascent transcript, whereas most non-coding RNA transcription relies on …
Phosphorylation of the RNA polymerase II C-terminal domain dictates transcription termination choice
RK Gudipati, T Villa, J Boulay, D Libri - Nature structural & molecular …, 2008 - nature.com
Cryptic unstable transcripts (CUTs) are short, 300–600-nucleotide (nt) RNA polymerase II
transcripts that are rapidly degraded by the nuclear RNA exosome in yeast. CUTs are …
transcripts that are rapidly degraded by the nuclear RNA exosome in yeast. CUTs are …