Termination of non-coding transcription in yeast relies on both a CTD-interaction domain and a CTD-mimic in Sen1

Z Han, O Jasnovidova, A Tudek, K Kubicek, D Libri… - bioRxiv, 2018 - biorxiv.org
Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non-coding RNAs (ncRNAs) without apparent function. Pervasive transcription poses a …

Termination of non‐coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD‐mimicking region in Sen1

Z Han, O Jasnovidova, N Haidara, A Tudek… - The EMBO …, 2020 - embopress.org
Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …

Modulated termination of non-coding transcription partakes in the regulation of gene expression

N Haidara, M Giannini, O Porrua - Nucleic Acids Research, 2022 - academic.oup.com
Pervasive transcription is a universal phenomenon leading to the production of a plethora of
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …

Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination

Z Han, D Libri, O Porrua - Nucleic Acids Research, 2017 - academic.oup.com
Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …

A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast

O Porrua, D Libri - Nature structural & molecular biology, 2013 - nature.com
Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

[HTML][HTML] Cell-cycle modulation of transcription termination factor Sen1

HE Mischo, Y Chun, KM Harlen, BM Smalec, S Dhir… - Molecular Cell, 2018 - cell.com
Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …

[HTML][HTML] Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome

X Chen, K Poorey, MN Carver, U Müller… - PLoS …, 2017 - journals.plos.org
Transcriptome studies on eukaryotic cells have revealed an unexpected abundance and
diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which …

[HTML][HTML] Single-molecule reconstruction of eukaryotic factor-dependent transcription termination

Y Xiong, W Han, C Xu, J Shi, L Wang, T Jin… - Nature …, 2024 - nature.com
Factor-dependent termination uses molecular motors to remodel transcription machineries,
but the associated mechanisms, especially in eukaryotes, are poorly understood. Here we …

[HTML][HTML] RNA polymerase II CTD tyrosine 1 is required for efficient termination by the Nrd1-Nab3-Sen1 pathway

P Collin, C Jeronimo, C Poitras, F Robert - Molecular cell, 2019 - cell.com
In Saccharomyces cerevisiae, transcription termination at protein-coding genes is coupled to
the cleavage of the nascent transcript, whereas most non-coding RNA transcription relies on …

Phosphorylation of the RNA polymerase II C-terminal domain dictates transcription termination choice

RK Gudipati, T Villa, J Boulay, D Libri - Nature structural & molecular …, 2008 - nature.com
Cryptic unstable transcripts (CUTs) are short, 300–600-nucleotide (nt) RNA polymerase II
transcripts that are rapidly degraded by the nuclear RNA exosome in yeast. CUTs are …