Multiplatform molecular test performance in indeterminate thyroid nodules

MA Lupo, AE Walts, JW Sistrunk… - Diagnostic …, 2020 - Wiley Online Library
Background Approximately 25% of thyroid nodule fine‐needle aspirates (FNAs) have
cytology that is indeterminate for malignant disease. Accurate risk stratification of these …

Performance of a multigene genomic classifier in thyroid nodules with indeterminate cytology: a prospective blinded multicenter study

DL Steward, SE Carty, RS Sippel, SP Yang… - JAMA …, 2019 - jamanetwork.com
Importance Approximately 20% of fine-needle aspirations (FNA) of thyroid nodules have
indeterminate cytology, most frequently Bethesda category III or IV. Diagnostic surgeries can …

Effectiveness of molecular testing techniques for diagnosis of indeterminate thyroid nodules: a randomized clinical trial

MJ Livhits, CY Zhu, EJ Kuo, DT Nguyen, J Kim… - JAMA …, 2021 - jamanetwork.com
Importance Approximately 20% of thyroid nodules display indeterminate cytology. Molecular
testing can refine the risk of malignancy and reduce the need for diagnostic …

Update on molecular testing for cytologically indeterminate thyroid nodules

M Nishino, M Nikiforova - Archives of pathology & …, 2018 - meridian.allenpress.com
Context.—Approximately 15% to 30% of thyroid nodules that undergo fine-needle aspiration
are classified as cytologically indeterminate, presenting management challenges for …

[HTML][HTML] The role of molecular testing for the indeterminate thyroid FNA

ED Rossi, L Pantanowitz, WC Faquin - Genes, 2019 - mdpi.com
Thyroid nodules are common in the adult population where a majority are benign and only
4.0% to 6.5% are malignant. Fine needle aspiration (FNA) is a key method used in the early …

Molecular testing of thyroid nodules: a review of current available tests for fine-needle aspiration specimens

M Zhang, O Lin - Archives of pathology & laboratory …, 2016 - meridian.allenpress.com
Context.—Fine-needle aspiration of thyroid nodules is a reliable diagnostic method to
determine the nature of thyroid nodules. Nonetheless, indeterminate cytology diagnoses …

The impact of benign gene expression classifier test results on the endocrinologist–patient decision to operate on patients with thyroid nodules with indeterminate fine …

DS Duick, JP Klopper, JC Diggans, L Friedman… - Thyroid, 2012 - liebertpub.com
Background: Seventy-five percent of thyroid nodules with indeterminate fine-needle
aspiration (FNA) cytology are found to be benign postoperatively. A novel genomic test, the …

Preoperative diagnosis of benign thyroid nodules with indeterminate cytology

EK Alexander, GC Kennedy, ZW Baloch… - … England Journal of …, 2012 - Mass Medical Soc
Background Approximately 15 to 30% of thyroid nodules evaluated by means of fine-needle
aspiration are not clearly benign or malignant. Patients with cytologically indeterminate …

[HTML][HTML] European thyroid association guidelines regarding thyroid nodule molecular fine-needle aspiration cytology diagnostics

R Paschke, S Cantara, A Crescenzi… - European thyroid …, 2017 - etj.bioscientifica.com
Molecular fine-needle aspiration (FNA) cytology diagnostics has the potential to address the
inherent limitation of FNA cytology which is an indeterminate (atypia of undetermined …

Cost impact of molecular testing for indeterminate thyroid nodule fine-needle aspiration biopsies

L Yip, C Farris, AS Kabaker, SP Hodak… - The Journal of …, 2012 - academic.oup.com
Introduction: Molecular testing of fine-needle aspiration (FNA) results helps diagnose thyroid
cancer, although the additional cost of this adjunct has not been studied. We hypothesized …