Regulation of terminal differentiation programs in the nervous system

O Hobert - Annual review of cell and developmental biology, 2011 - annualreviews.org
The generation of individual neuron types in the nervous system is a multistep process
whose endpoint is the expression of neuron type–specific batteries of terminal differentiation …

Binary fate decisions in differentiating neurons

D Jukam, C Desplan - Current opinion in neurobiology, 2010 - Elsevier
Neural cell fate programs must generate an enormous number of neurons with distinct adult
functions. The decision to choose one neuronal subtype from two alternatives—a binary fate …

Maintenance of postmitotic neuronal cell identity

ES Deneris, O Hobert - Nature neuroscience, 2014 - nature.com
The identity of specific cell types in the nervous system is defined by the expression of
neuron type–specific gene batteries. How the expression of such batteries is initiated during …

Neuronal identity control by terminal selectors in worms, flies, and chordates

O Hobert, P Kratsios - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …

Markers in vertebrate neurogenesis

RD Corral, KG Storey - Nature Reviews Neuroscience, 2001 - nature.com
Embryologists have long used morphological characteristics, and more recently marker
genes, to identify neural tissue and to test the neural-inducing activity of specific cell …

A map of terminal regulators of neuronal identity in Caenorhabditis elegans

O Hobert - Wiley Interdisciplinary Reviews: Developmental …, 2016 - Wiley Online Library
Our present day understanding of nervous system development is an amalgam of insights
gained from studying different aspects and stages of nervous system development in a …

Regulatory logic of neuronal diversity: terminal selector genes and selector motifs

O Hobert - Proceedings of the National Academy of …, 2008 - National Acad Sciences
Individual neuronal cell types are defined by the expression of unique batteries of terminal
differentiation genes. The elucidation of the cis-regulatory architecture of several distinct …

Terminal selectors of neuronal identity

O Hobert - Current topics in developmental biology, 2016 - Elsevier
The analysis of the developmental programs that define many different neuron types in the
nematode Caenorhabditis elegans has revealed common themes in how distinct terminal …

Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression

G Feng, P Yi, Y Yang, Y Chai, D Tian, Z Zhu… - …, 2013 - journals.biologists.com
Neuroblasts generate neurons with different functions by asymmetric cell division, cell cycle
exit and differentiation. The underlying transcriptional regulatory pathways remain elusive …

Molecular logic of neocortical projection neuron specification, development and diversity

LC Greig, MB Woodworth, MJ Galazo… - Nature Reviews …, 2013 - nature.com
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …