Regulation of terminal differentiation programs in the nervous system
O Hobert - Annual review of cell and developmental biology, 2011 - annualreviews.org
The generation of individual neuron types in the nervous system is a multistep process
whose endpoint is the expression of neuron type–specific batteries of terminal differentiation …
whose endpoint is the expression of neuron type–specific batteries of terminal differentiation …
Binary fate decisions in differentiating neurons
Neural cell fate programs must generate an enormous number of neurons with distinct adult
functions. The decision to choose one neuronal subtype from two alternatives—a binary fate …
functions. The decision to choose one neuronal subtype from two alternatives—a binary fate …
Maintenance of postmitotic neuronal cell identity
ES Deneris, O Hobert - Nature neuroscience, 2014 - nature.com
The identity of specific cell types in the nervous system is defined by the expression of
neuron type–specific gene batteries. How the expression of such batteries is initiated during …
neuron type–specific gene batteries. How the expression of such batteries is initiated during …
Neuronal identity control by terminal selectors in worms, flies, and chordates
O Hobert, P Kratsios - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …
Markers in vertebrate neurogenesis
Embryologists have long used morphological characteristics, and more recently marker
genes, to identify neural tissue and to test the neural-inducing activity of specific cell …
genes, to identify neural tissue and to test the neural-inducing activity of specific cell …
A map of terminal regulators of neuronal identity in Caenorhabditis elegans
O Hobert - Wiley Interdisciplinary Reviews: Developmental …, 2016 - Wiley Online Library
Our present day understanding of nervous system development is an amalgam of insights
gained from studying different aspects and stages of nervous system development in a …
gained from studying different aspects and stages of nervous system development in a …
Regulatory logic of neuronal diversity: terminal selector genes and selector motifs
O Hobert - Proceedings of the National Academy of …, 2008 - National Acad Sciences
Individual neuronal cell types are defined by the expression of unique batteries of terminal
differentiation genes. The elucidation of the cis-regulatory architecture of several distinct …
differentiation genes. The elucidation of the cis-regulatory architecture of several distinct …
Terminal selectors of neuronal identity
O Hobert - Current topics in developmental biology, 2016 - Elsevier
The analysis of the developmental programs that define many different neuron types in the
nematode Caenorhabditis elegans has revealed common themes in how distinct terminal …
nematode Caenorhabditis elegans has revealed common themes in how distinct terminal …
Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression
Neuroblasts generate neurons with different functions by asymmetric cell division, cell cycle
exit and differentiation. The underlying transcriptional regulatory pathways remain elusive …
exit and differentiation. The underlying transcriptional regulatory pathways remain elusive …
Molecular logic of neocortical projection neuron specification, development and diversity
LC Greig, MB Woodworth, MJ Galazo… - Nature Reviews …, 2013 - nature.com
The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …
neuronal subtypes generated during development under precise molecular regulation. In …