The myocardium of the heart is composed of multiple highly specialized myocardial
lineages, including those of the ventricular and atrial myocardium, and the specialized …

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …

The heart develops from two bilateral heart fields that are formed during early gastrulation. In
recent years, signaling pathways that specify cardiac mesoderm have been extensively …

The vertebrate heart is composed of a limited number of well-characterized cell types and
therefore is an excellent system in which to study lineage-determination events and …

The heart is the first organ to form during embryogenesis and its circulatory function is critical
from early on for the viability of the mammalian embryo. Developmental abnormalities of the …

▪ Abstract Recent discoveries have led to a greater appreciation of the diverse mechanisms
that underlie cardiac morphogenesis. Genetic strategies (primarily gene targeting …

The heart is the first organ to form during embryonic development. Given the complex nature
of cardiac differentiation and morphogenesis, it is not surprising that some form of congenital …

Organogenesis of the vertebrate heart involves a complex sequence of events initiating with
specification and differentiation of myocardial and endocardial cells in anterior lateral …

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-
dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that …

During the last decade, a variety of morphological, physiological, and biochemical studies
have provided an improved definition of the alterations in myocardial structure and function …