Microglia, once viewed as static bystanders with limited homeostatic functions, are now
considered key players in the development of neuroinflammatory and neurodegenerative …

Microglia are universal sensors of alterations in CNS physiology. These cells integrate
complex molecular signals and undergo comprehensive phenotypical remodeling to adapt …

The importance of neuroglia in maintaining normal brain function under physiological and
pathological conditions has been supported by growing evidence in recent years. The most …

The integrity of central and peripheral nervous system myelin is affected in numerous lipid
metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily …

Microglia become increasingly dysfunctional with aging and contribute to the onset of
neurodegenerative disease (NDs) through defective phagocytosis, attenuated cholesterol …

Lipids play crucial roles in cell signaling and various physiological processes, especially in
the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative …

Microglia, the tissue macrophages of the brain, have under healthy conditions a resting
phenotype that is characterized by a ramified morphology. With their fine processes …

Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

In response to various types of environmental and cellular stress, microglia rapidly activate
and exhibit either pro-or anti-inflammatory phenotypes to maintain tissue homeostasis …