The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

Pluripotent stem cells can be expanded seemingly indefinitely in culture, maintain a normal
karyotype and have the potential to generate any cell type in the body. As such they …

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No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have
made in the few years since somatic cells were first reprogrammed to pluripotency. But what …

Recent landmark experiments have shown that transient overexpression of a small number
of transcription factors can reprogram differentiated cells into induced pluripotent stem (iPS) …

Induced pluripotent stem cells offer unprecedented potential for disease research, drug
screening, toxicology and regenerative medicine. However, the process of reprogramming is …

Induction of pluripotency by transcription factors has become a commonplace method to
produce pluripotent stem cells. Great strides have been made in our understanding of the …

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has
rekindled an interest in earlier studies showing that transcription factors can directly convert …

Pluripotent cells, such as embryonic stem cells, are invaluable tools for research and can
potentially serve as a source of cell-and tissue-replacement therapy. Rejection after …

Reprogramming of somatic cells is a valuable tool to understand the mechanisms of
regaining pluripotency and further opens up the possibility of generating patient-specific …