Single-molecule biosensors serve the unmet need for real time detection of individual
biological molecules in the molecular crowd with high specificity and accuracy, uncovering …

The ability to measure many single molecules simultaneously in large and complex samples
is critical to the translation of single-molecule sensors for practical applications in biomarker …

With the deepening of our understanding in life science, molecular biology, nanotechnology,
optics, electrochemistry and other areas, an increasing number of biosensor design …

CRISPR diagnostics (CRISPR-Dx) offer a wide range of enhancements compared to
traditional nanobiosensors by taking advantage of the excellent trans-cleavage activity of the …

The rapid spread of epidemic diseases (ie, coronavirus disease 2019 (COVID-19)) has
contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive …

Point-of-care testing (POCT), as one part of in vitro diagnostic (IVD), has been gradually
used in early diagnosis and personalized treatment in the clinics. Accurate and sensitive …

Portable devices capable of rapid disease detection and health monitoring are crucial to
decentralizing diagnostics from clinical laboratories to the patient point-of-need. Although …

One of the frontiers in the field of biosensors is the ability to quantify specific target
molecules with enough precision to count individual units in a test sample, and to observe …

Abstract (Bio) analytical applications often require efficient signal enhancement strategies
that are directly integrated into the biorecognition process. Nanomaterials are increasingly …

Measurement science has been converging to smaller and smaller samples, such that it is
now possible to detect single molecules. This Review focuses on the next generation of …