The role of podoplanin in tumor progression and metastasis

M Raica, AM Cimpean, D Ribatti - Anticancer research, 2008 - ar.iiarjournals.org
In the last decade, much data has been generated concerning the molecular mechanisms of
lymphangiogenesis and its significance in pathological conditions. This was mainly due to …

Immunohistochemical detection of the lymphatic marker podoplanin in diverse types of human cancer cells using a novel antibody

T Kono, M Shimoda, M Takahashi… - International …, 2007 - spandidos-publications.com
The mucin-type transmembrane glycoprotein podoplanin (also known as T1α, gp38 or
Aggrus) is well established as one of the lymphatic-specific markers. Podoplanin was also …

[HTML][HTML] Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

LN Cueni, I Hegyi, JW Shin, A Albinger-Hegyi… - The American journal of …, 2010 - Elsevier
The membrane glycoprotein podoplanin is expressed by several types of human cancers
and might be associated with their malignant progression. Its exact biological function and …

Overexpression of podoplanin in oral cancer and its association with poor clinical outcome

P Yuan, S Temam, A El‐Naggar, X Zhou, DD Liu… - Cancer, 2006 - Wiley Online Library
BACKGROUND. Podoplanin is a mucin‐like glycoprotein that is important in
lymphangiogenesis but not blood vessel formation. Recent studies suggested a potential …

Podoplanin expression in cancer‐associated fibroblasts predicts aggressive behavior in melanoma

S Kan, E Konishi, T Arita, C Ikemoto… - Journal of cutaneous …, 2014 - Wiley Online Library
Background Recent studies have showed podoplanin expression in several tumors, which
has been associated with lymph node metastasis and poor prognosis. Podoplanin …

Role of podoplanin expression in squamous cell carcinoma of upper aerodigestive tract

WY Chuang, YS Chang, CJ Yeh, YC Wu, C Hsueh - 2013 - digitum.um.es
Podoplanin, a type-1 transmembrane glycoprotein, was originally named due to its
expression in renal podocytes of rats. It was subsequently detected in a variety of normal …

Enhanced expression of podoplanin in oral carcinomas in situ and squamous cell carcinomas

A Funayama, J Cheng, S Maruyama, M Yamazaki… - Pathobiology, 2011 - karger.com
Objective: Podoplanin, a known lymphatic endothelial cell marker, has been reported to be
expressed in various types of cancer. To elucidate the expression of podoplanin in …

[HTML][HTML] Podoplanin-a small glycoprotein with many faces

M Ugorski, P Dziegiel, J Suchanski - American journal of cancer …, 2016 - ncbi.nlm.nih.gov
Podoplanin is a small membrane glycoprotein with a large number of O-glycoside chains
and therefore it belongs to mucin-type proteins. It can be found on the surface of many types …

Tumor cell expression of podoplanin correlates with nodal metastasis in esophageal squamous cell carcinoma

WY Chuang, CJ Yeh, YC Wu, YK Chao… - Histology and …, 2009 - digitum.um.es
Podoplanin is a mucin-like glycoprotein expressed in the lymphatic endothelium. It has been
suggested to play a role in lymphangiogenesis, since podoplanin deficient mice were found …

[HTML][HTML] Significance of podoplanin expression in cancer-associated fibroblasts: a comprehensive review

B Pula, W Witkiewicz, P Dziegiel… - International …, 2013 - spandidos-publications.com
Cancer-associated fibroblasts (CAFs) are well-known to be part of the tumor
microenvironment. This heterogeneous population of cells of the tumor microenvironment …