[HTML][HTML] The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress
G Raghu, M Berk, PA Campochiaro… - Current …, 2021 - ncbi.nlm.nih.gov
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
N‐acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
R Bavarsad Shahripour, MR Harrigan… - Brain and …, 2014 - Wiley Online Library
Background There is an expanding field of research investigating the benefits of medicines
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …
with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC) …
The promise of N-acetylcysteine in neuropsychiatry
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of
multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant …
multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant …
[HTML][HTML] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
[HTML][HTML] Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a
mucolytic. Over the past decade, there has been growing evidence for the use of NAC in …
mucolytic. Over the past decade, there has been growing evidence for the use of NAC in …
Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease
L Calzetta, MG Matera, P Rogliani… - Expert Review of …, 2018 - Taylor & Francis
ABSTRACT Introduction: N-acetyl-l-cysteine (NAC), a derivative of the naturally occurring
amino acid l-cysteine, is a mucolytic agent that may also act as an antioxidant by providing …
amino acid l-cysteine, is a mucolytic agent that may also act as an antioxidant by providing …
A minireview on N-acetylcysteine: an old drug with new approaches
IE Dhouib, M Jallouli, A Annabi, N Gharbi, S Elfazaa… - Life sciences, 2016 - Elsevier
Abstract N-acetylcysteine (NAC), a cysteine pro-drug and glutathione precursor has been
used in therapeutic practices for several decades, as a mucolytic agent and for the treatment …
used in therapeutic practices for several decades, as a mucolytic agent and for the treatment …
The chemistry and biological activities of N-acetylcysteine
Y Samuni, S Goldstein, OM Dean, M Berk - Biochimica et Biophysica Acta …, 2013 - Elsevier
BACKGROUND: N-acetylcysteine (NAC) has been in clinical practice for several decades. It
has been used as a mucolytic agent and for the treatment of numerous disorders including …
has been used as a mucolytic agent and for the treatment of numerous disorders including …
Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits
GF Rushworth, IL Megson - Pharmacology & therapeutics, 2014 - Elsevier
Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
N-Acetylcysteine (NAC): Impacts on Human Health
MCS Tenório, NG Graciliano, FA Moura, ACM Oliveira… - Antioxidants, 2021 - mdpi.com
N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …