Genetic interactions identify combinations of genetic variants that impinge on phenotype.
With whole-genome sequence information available for thousands of individuals within a …

Global quantitative analysis of genetic interactions is a powerful approach for deciphering
the roles of genes and mapping functional relationships among pathways. Using colony size …

INTRODUCTION Genetic interactions are identified when variants in different genes
combine to generate an unusual phenotype compared with the expected combined effect of …

Experiments in model organisms report abundant genetic interactions underlying
biologically important traits, whereas quantitative genetics theory predicts, and data support …

Genetic interactions are highly informative for deciphering the underlying functional
principles that govern how genes control cell processes. Recent developments in Synthetic …

Genetic interactions influencing a phenotype of interest can be identified systematically
using libraries of genetic tools that perturb biological systems in a defined manner …

Understanding the relationship between the genotypes and phenotypes of individuals is key
for identifying genetic variants responsible for disease and developing successful …

A key goal of biology is to construct networks that predict complex system behavior. We
combine multiple types of molecular data, including genotypic, expression, transcription …

Genetic interactions between mutations and standing polymorphisms can cause mutations
to show distinct phenotypic effects in different individuals. To characterize the genetic …

A genetic interaction (GI) between two genes generally indicates that the phenotype of a
double mutant differs from what is expected from each individual mutant. In the last decade …