This review discusses an approach to determining the cause of neonatal encephalopathy,
as well as current evidence on resuscitation and subsequent management of hypoxic …

Neonatal encephalopathy after perinatal hypoxic-ischemic insult is a major contributor to
global child mortality and morbidity. Brain injury in term infants in response to hypoxic …

Although major cooling trials (and subsequent guidelines) excluded babies with mild
encephalopathy, anecdotal evidence suggests that cooling is often offered to these infants …

Objectives To examine if therapeutic hypothermia reduces the composite outcome of death,
moderate or severe disability at 18 months or more after mild neonatal encephalopathy …

In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

Neonatal encephalopathy (NE) is associated with high mortality and morbidity. Factors
predisposing to NE can be antenatal, perinatal, or a combination of both. Antenatal maternal …

Infants with moderate to severe neonatal encephalopathy (NE) benefit significantly from
therapeutic hypothermia, with reduced risk of death or disability. However, the need for …

Therapeutic hypothermia (TH) is now well established to improve intact survival after
neonatal encephalopathy (NE). However, many questions could not be addressed by the …

Background We previously reported early results of a randomized trial of whole-body
hypothermia for neonatal hypoxic–ischemic encephalopathy showing a significant reduction …

Perinatal hypoxic-ischemic encephalopathy (HIE), a subset of neonatal encephalopathy, is
associated with high neonatal mortality and severe long-term neurologic morbidity. Until …