RNA turnover is an integral part of cellular RNA homeostasis and gene expression
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …

Eukaryotic RNA polymerase II produces an astounding diversity of transcripts. These may
need to be 5′ capped, spliced, polyadenylated, and packaged with proteins before their …

Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which
are subject to extensive processing. These processes are inherently error-prone, and cells …

Nuclear RNA Turnover: Cell Skip to Main Content Advertisement Cell This journal offers
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Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …

Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …

General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the
quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a …

RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

Fission yeast Cid14, a component of the TRAMP (Cid14/Tr f4-A ir1-M tr4 p olyadenylation)
complex, polyadenylates nuclear RNA and stimulates degradation by the exosome for RNA …

Recent studies demonstrate that the factors involved in mRNA processing specify the fate of
a transcript. The mRNA is either committed for export to the cytoplasm or accumulates in the …