Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

Fibrosis, the progressive accumulation of connective tissue that occurs in response to injury,
causes irreparable organ damage and may result in organ failure. The few available …

Fibrosis, or the accumulation of extracellular matrix molecules that make up scar tissue, is a
common result of chronic tissue injury. Advances in the clinical management of fibrotic …

Fibrosis, a complex process of abnormal tissue healing which inevitably leads to loss of
physiological organ structure and function, is a worldwide leading cause of death. Despite a …

Hepatic fibrosis, characterized by excessive accumulation of extracellular matrix (ECM)
proteins leading to liver dysfunction, is a growing cause of mortality worldwide …

Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive
necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward …

Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …

Liver fibrosis reflects sustained liver injury often from multiple, simultaneous factors. Whilst
the presence of mild fibrosis on biopsy can be a reassuring finding, the identification of …

The diagnostic assessment of liver fibrosis, a major determinant of disease severity, is an
important step in the management of patients with chronic liver diseases. Liver biopsy is still …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …