Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus
must be supported within the pregnant female for the required gestational period …

Formation of the placenta is a crucial step in mammalian pregnancy. Apart from its function
in ensuring an optimal supply of nutrients and oxygen to the fetus, the placenta is also the …

Pregnancy is an immune paradox in which the mother must tolerate the fetus, a
semiallograft, while at the same time maintain immune defense against pathogens. From the …

During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

The traditional way to study the immunology of pregnancy follows the classical
transplantation model, which views the fetus as an allograft. A more recent approach, which …

The adaptive immune system of placental mammals has evolved to tolerate the fetus.
Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion …

Highlights•Decidual natural killer (dNK) cells transfer anti-microbial peptides to placental
trophoblasts to defend against infections.•Newly described maternal placenta-associated …

Immune mechanisms at the maternal-fetal interface: perspectives and challenges | Nature
Immunology Skip to main content Thank you for visiting nature.com. You are using a browser …

Immune cells adapt their phenotypic and functional characteristics in response to the tissue
microenvironment within which they traffic and reside. The fetomaternal interface, consisting …

Antigen‐presenting molecules vary between individuals of the same species, making it more
difficult for pathogens to evade immune recognition and spread through the whole …