POU domain factors are transcriptional regulators characterized by a highly conserved DNA-
binding domain referred to as the POU domain. The structure of the POU domain has been …

The POU homeodomain containing transcriptional activator POU1F1, formerly called Pit1 or
GHF-1, is required for the embryological determination and postnatal secretory function of …

Pit-1, a member of the POU-homeo domain protein family, is one of the transcription factors
responsible for anterior pituitary development and pituitary-specific gene expression. Here …

The anterior pituitary gland provides a model for investigating the molecular basis for the
appearance of phenotypically distinct cell types, within an organ, a central question in …

Characterization of Brn-3.0 and identification of a highly related member (Brn-3.1) of the
class IV POU-domain family suggest potential roles of Brn-3.0 in the development of retinal …

The ubiquitously expressed mammalian POU-domain protein Oct-1 specifically recognizes
two classes of cis-acting regulatory elements that bear little sequence similarity, the octamer …

The POU domain is a 150-160 amino acid region consisting of a 75-82 amino acid POU-
specific domain, a short variable linker region, and a 60 amino acid POU homeodomain …

The pituitary-specific transcription factor Pit-1/GHF1 regulates the expression of PRL, GH,
and TSH beta genes through binding to specific regions of the promoters of these genes …

Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of
growth hormone and prolactin genes. In three unrelated Japanese children with combined …

Pit-1 is a member of the POU family of transcription factors regulating mammalian
development. Pit-1 is thought to be the major cell-specific activator of both the somatotrophs …