The successful resolution of inflammation is dependent upon the coordinated transition from
the initial recruitment of neutrophils to a more sustained population of mononuclear cells. IL …

Interleukin (IL)-6 signaling through its soluble receptor (IL-6 transsignaling) directs transition
between innate and acquired immune responses by orchestrating the chemokine-directed …

Interleukin-4 (IL-4) receptor (IL-4R) signaling plays a pivotal role in type 2 immune
responses. Type 2 immunity ensures several host-protective processes such as defense …

Inflammation is counterbalanced by anti-inflammatory cytokines such as IL-10, in which
Stat3 mediates the signaling pathway. In this study, we demonstrate that resident …

During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of
neutrophils, which are later replaced by a more sustained population of mononuclear cells …

Background/Aims: Interleukin-17 (IL-17) is a major pro-inflammatory cytokine that initiates
and maintains inflammation. However, the molecular mechanisms as to how IL-17 …

There is general agreement that signal transducer and activation of transcription 3 (STAT3)
is required to mediate the anti-inflammatory activities of interleukin (IL)-10. However, STAT3 …

Regulated recruitment and clearance of neutrophils (PMN) is the hallmark of competent host
defense and resolution of inflammation. We now report that IFN-γ controls PMN infiltration …

We have previously demonstrated that STAT3 hyperactivation via the interleukin 6 (IL-6)
cytokine family receptor gp130 in gp130 Y757F/Y757F mice leads to numerous …

Antigen-induced eosinophil recruitment into the airways of sensitized mice is mediated by
CD4+ T cells and their cytokines, especially IL-5. In this study, we found that the antigen …