CD109 acts as a gatekeeper of the epithelial trait by suppressing epithelial to mesenchymal transition in squamous cell carcinoma cells in vitro

S Zhou, SD da Silva, PM Siegel, A Philip - Scientific Reports, 2019 - nature.com
There is increasing evidence that the expression of CD109, a GPI-anchored cell surface
protein is dysregulated in squamous cell carcinoma (SCC). However, the functional role of …

Up‐regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity

S Hagiwara, Y Murakumo, T Sato, T Shigetomi… - Cancer …, 2008 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol (GPI)–anchored glycoprotein whose expression is
up‐regulated in squamous cell carcinomas (SCCs) of the lung, esophagus, and uterus. The …

CD109 and squamous cell carcinoma

R Qi, F Dong, Q Liu, Y Murakumo, J Liu - Journal of Translational …, 2018 - Springer
Squamous cell carcinoma (SCC) is well-known for its high rate of metastasis with poor
prognosis. CD109 is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein …

CD109 mediates tumorigenicity and cancer aggressiveness via regulation of EGFR and STAT3 signalling in cervical squamous cell carcinoma

XT Mo, THY Leung, HWM Tang, MKY Siu… - British Journal of …, 2020 - nature.com
Background CD109 was involved in the tumorigenesis and progression of various cancers
via TGF-β1 signalling and STAT3 activation. As CD109 is strongly expressed in cervical …

CD109 is a critical determinant of EGFR expression and signaling, and tumorigenicity in squamous cell carcinoma cells

S Zhou, A Hassan, T Kungyal, S Tabariès, JLRG Luna… - Cancers, 2022 - mdpi.com
Simple Summary Squamous cell carcinoma is a type of cancer resulting from cancer of the
squamous cells that line some organs of the body such as the skin, lungs, and vulva. It is …

CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

S Mii, A Enomoto, Y Shiraki, T Taki… - Pathology …, 2019 - Wiley Online Library
CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein and a member of the α2‐
macroglobulin/C3, C4, C5 family of thioester‐containing proteins first identified as being …

[HTML][HTML] CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells

JM Zhang, Y Murakumo, S Hagiwara, P Jiang… - Biochemical and …, 2015 - Elsevier
CD109 is a glycosylphosphatidylinositol-anchored cell surface protein that is frequently
detected in squamous cell carcinomas. CD109 is a negative regulator of TGF-β1 signaling in …

[HTML][HTML] Suppression of skin tumorigenesis in CD109-deficient mice

M Sunagawa, S Mii, A Enomoto, T Kato, Y Murakumo… - Oncotarget, 2016 - ncbi.nlm.nih.gov
CD109 is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed in
several types of human cancers, particularly squamous cell carcinomas. We previously …

CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF‐β signaling

T Taki, Y Shiraki, A Enomoto, L Weng, C Chen… - Cancer …, 2020 - Wiley Online Library
Stromal invasion is considered an important prognostic factor in patients with lung
adenocarcinoma. The mechanisms underlying the formation of tumor stroma and stromal …

[HTML][HTML] CD109 expression is upregulated in penile squamous cell carcinoma

F Dong, J Wang, Y Xu, Z Cheng, X Chen… - Oncology …, 2017 - spandidos-publications.com
Cluster of differentiation (CD) 109 is a glycosylphosphatidylinositol‑anchored cell surface
glycoprotein and a co‑receptor for transforming growth factor β. The expression of CD109 …