[HTML][HTML] A study on the toxic effects of doxorubicin on the histology of certain organs

P Shivakumar, MU Rani, AG Reddy… - Toxicology …, 2012 - ncbi.nlm.nih.gov
In the present study, effect of doxorubicin at 2 mg/kg b. wt.(i/p), alone, once in a wk for 4 wks
and in combination with vitamin E at 250 and 500 mg/kg b. wt., orally, daily for 4 wks was …

Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin

Y Kalender, M Yel, S Kalender - Toxicology, 2005 - Elsevier
Doxorubicin (DXR) is an anthracycline antibiotic, broady used in tumor therapy. In the
present study we investigated whether vitamin E and catechin can reduce the toxic effects of …

Alpha-tocopherol reduces doxorubicin-induced toxicity in rats--histological and biochemical evidences.

A Geetha, R Sankar, T Marar, CS Devi - Indian journal of physiology …, 1990 - europepmc.org
The beneficial effect of alpha-tocopherol on doxorubicin-induced toxicity was studied in rats.
alpha-Tocopherol (400 mg/kg/day) was administered orally, daily for a period of 2 months …

Effect of vitamin A administration on resistance of rat heart against doxorubicin-induced cardiotoxicity and lethality.

L Tesoriere, M Ciaccio, M Valenza, A Bongiorno… - … of Pharmacology and …, 1994 - ASPET
The peroxyl radical-scavenging activity of vitamin A has been exploited to obtain protection
against peroxidative damages induced in rat heart by administration of an acute dose of …

Activity of d, l‐α‐tocopherol (vitamin e) against cardiotoxicity induced by doxorubicin and doxorubicin with cyclophosphamide in mice

SK Bjelogrlic, J Radic, V Jovic… - Basic & clinical …, 2005 - Wiley Online Library
The aim of this study was to investigate the cardioprotective activity of vitamin E against
doxorubicin alone and doxorubicin in combination with cyclophosphamide in mice. Female …

Protective effect of N-acetylcysteine, caffeic acid and vitamin E on doxorubicin hepatotoxicity

A Gokcimen, A Cim, HT Tola… - Human & …, 2007 - journals.sagepub.com
The aim of this study was to compare the possible protective effects of N-acetylcysteine
(NAC), caffeic acid (CAPE) and vitamin E (Vit-E) on doxorubicin-induced hepatotoxicity …

Means of evaluation and protection from doxorubicin-induced cardiotoxicity and hepatotoxicity in rats

I Salouege, RB Ali, DB Saïd, N Elkadri… - Journal of Cancer …, 2014 - journals.lww.com
Objectives: This work is aimed on the study of doxorubicin cardiotoxicity and hepatotoxicity
in rats and the evaluation of protective effect of trimetazidine administrated concomitantly …

The role of lipid peroxidation in acute doxorubicin‐induced cardiotoxicity as studied in rat isolated heart

RHM Julicher, L Sterrenberg, A Bast… - Journal of pharmacy …, 1986 - Wiley Online Library
Doxorubicin induces an acute cardiotoxicity that becomes manifest in isolated hearts as a
deterioration in mechanical function. The oxidative component in this myocardial damage …

Comparison of the severity of the chronic cardiotoxicity produced by doxorubicin in normotensive and hypertensive rats

EH Herman, AN El-Hage, VJ Ferrans… - Toxicology and applied …, 1985 - Elsevier
A comparison was made of the severity of chronic doxorubicin cardiotoxicity in adult male
spontaneously hypertensive rats (SHR) and in genetically related normotensive Wistar …

Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs

Y Xin, S Zhang, L Gu, S Liu, H Gao, Z You… - Biological and …, 2011 - jstage.jst.go.jp
Biol. Pharm. Bull. 34(10): 1523-1526 (2011) Page 1 Doxorubicin (DOX), a quinone-containing
anthracycline antineoplastic, is used for the treatment of solid and hematopoietic tumors …