Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty
acid palmitate to cysteine residues, which influences trafficking, localization, and protein …

S-palmitoylation (S-PALM) is a lipid modification that involves the linkage of a fatty acid
chain to cysteine residues of the substrate protein. This common posttranslational …

Protein lipidation is a common post-translational modification of proteins that plays an
important role in human physiology and pathology. One form of protein lipidation, S …

Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid,
palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Postsynaptic density (PSD)-95, the most abundant postsynaptic scaffolding protein, plays a
pivotal role in synapse development and function. Continuous palmitoylation cycles on PSD …

Modification of proteins with the lipid palmitate regulates targeting to specific vesicular
compartments and synaptic membranes. Mounting evidence indicates that this lipid …

Protein palmitoylation is the most common posttranslational lipid modification; its reversibility
mediates protein shuttling between intracellular compartments. A large family of DHHC (Asp …

Palmitoylation—the post-translational modification of proteins with the lipid palmitate—has
emerged as an important mechanism for regulating protein trafficking and function. Classic …

Palmitoylation is a lipid modification that plays a critical role in protein trafficking and function
throughout the nervous system. Palmitoylation of PSD-95 is essential for its regulation of …