Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer
subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and …

Background Triple-negative breast cancer (TNBC) is the most heterogeneous and malignant
subtype of breast cancer (BC). TNBC is defined by the absence of expression of estrogen …

Never in mitosis gene A (NIMA)-related kinase-8 (NEK8) is involved in cell cycle
progression, cytoskeleton development, and DNA damage repair. However, its role in breast …

Triple-negative breast cancer (TNBC) is the deadliest subtype of breast cancer owing to the
lack of effective therapeutic targets. Splicing factor 3a subunit 2 (SF3A2), a poorly defined …

Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer
development and progression, and a role for NEK5, one of the least studied members, in …

The development of triple-negative breast cancer (TNBC) is critically regulated by certain
tumor-microenvironment-associated cells called mesenchymal stem/stromal cells (MSCs) …

Purpose Breast cancer remains a prominent global disease affecting women worldwide
despite the emergence of novel therapeutic regimens. Metastasis is responsible for most …

SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired
amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 …

NEK5, a contraction of NIMA Related Kinase 5, has been shown to regulate the centrosome
integrity of cells though; it has been little described in cancer. Herein, to explore the …

Abstract Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to
centrosomes and kinetochores, controlling centrosome separation, chromosome …