Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …

Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale1-3. Here we …

Cancer cells survive cellular crisis through telomere maintenance mechanisms. We report
telomere lengths in 18,430 samples, including tumors and non-neoplastic samples, across …

Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

The benign-to-malignant transition in human breast cancer is associated with a marked
increase in chromosomal aberrations. A new study suggests that telomere dysfunction and …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …

Abstract The International Cancer Genome Consortium (ICGC) was launched to coordinate
large-scale cancer genome studies in tumours from 50 different cancer types and/or …

Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …

Abstract The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis
methods to identify somatic variants across thousands of tumours. Here we present data and …

Telomeres consist of short repeated sequences that are synthesized by telomerase, a
ribonucleo-protein DMA polymerase1–4. Telomerase activity is present in many tumours …