Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

How do antidepressants elicit an antidepressant response? Here, we review accumulating
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …

Brain-derived neurotrophic factor (BDNF) is a member of the structurally and functionally
homologous neurotrophin family. It is the most widely distributed trophic factor in the brain …

Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase TrkB support
neuronal survival during development and promote connectivity and plasticity in the adult …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

There is a growing body of evidence demonstrating that stress decreases the expression of
brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that …

Major depression is associated with reduced volumes in the hippocampus and prefrontal
cortex, whereas antidepressant treatments promote several forms of neuronal plasticity …

Preclinical and clinical studies demonstrate that neurotrophic factors play critical roles in the
etiology and treatment of depression. While the mechanisms underlying the therapeutic …

The'neurotrophin hypothesis of depression'is based largely on correlations between stress
or antidepressant treatment and down-or upregulation, respectively, of brain-derived …