Mitochondrial dysfunction in Parkinson's disease: from mechanistic insights to therapy

XY Gao, T Yang, Y Gu, XH Sun - Frontiers in aging neuroscience, 2022 - frontiersin.org
Parkinson's disease (PD) is one of the most common neurodegenerative movement
disorders worldwide. There are currently no cures or preventative treatments for PD …

Mitochondrial dysfunction in Parkinson's disease: new mechanistic insights and therapeutic perspectives

JS Park, RL Davis, CM Sue - Current neurology and neuroscience reports, 2018 - Springer
Abstract Purpose of Review Parkinson's disease (PD) is a complex neurodegenerative
disorder, the aetiology of which is still largely unknown. Overwhelming evidence indicates …

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Current perspective of mitochondrial biology in Parkinson's disease

NA Kaidery, B Thomas - Neurochemistry International, 2018 - Elsevier
Parkinson's disease (PD) is one of the most common neurodegenerative movement disorder
characterized by preferential loss of dopaminergic neurons of the substantia nigra pars …

[HTML][HTML] Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

R Banerjee, AA Starkov, MF Beal, B Thomas - Biochimica et Biophysica …, 2009 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder with
unknown etiology. It is marked by widespread neurodegeneration in the brain with profound …

The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease

A Camilleri, N Vassallo - CNS neuroscience & therapeutics, 2014 - Wiley Online Library
Parkinson's disease (PD) is an incurable neurodegenerative disorder leading to progressive
motor impairment and for which there is no cure. From the first postmortem account …

Mitochondria and Parkinson's disease: clinical, molecular, and translational aspects

M Borsche, SL Pereira, C Klein… - Journal of Parkinson's …, 2021 - content.iospress.com
Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondrial biology and Parkinson's disease

C Perier, M Vila - Cold Spring Harbor …, 2012 - perspectivesinmedicine.cshlp.org
Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Fighting Parkinson's disease: The return of the mitochondria

K Zambrano, D Barba, K Castillo, L Noboa… - Mitochondrion, 2022 - Elsevier
Parkinson's disease (PD) is the most common neurodegenerative movement disorder,
worldwide. PD neuro-energetically affects the extrapyramidal system, by the progressive …

Mitochondrial dysfunction in Parkinson's disease–a key disease hallmark with therapeutic potential

MT Henrich, WH Oertel, DJ Surmeier… - Molecular …, 2023 - Springer
Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …