Selenium unmasks protective iron armor: a possible defense against cutaneous inflammation and cancer

JL Arbiser, MY Bonner, N Ward, J Elsey… - Biochimica et Biophysica …, 2018 - Elsevier
Background A link between selenium deficiency and inflammatory skin diseases have been
noted by many, but this link is still not well understood. We have previously studied the …

Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice

K Felix, S Gerstmeier, A Kyriakopoulos, OMZ Howard… - Cancer research, 2004 - AACR
The role of the micronutrient, selenium, in human cancers associated with chronic
inflammations and persistent infections is poorly understood. Peritoneal plasmacytomas …

[HTML][HTML] Selenium stimulates the antitumour immunity: Insights to future research

A Razaghi, M Poorebrahim, D Sarhan… - European Journal of …, 2021 - Elsevier
Selenium is an essential trace element for regulating immune functions through redox-
regulating activity of selenoproteins (eg glutathione peroxidase), protecting immune cells …

Selenium and GPX4, a vital symbiosis

JPF Angeli, M Conrad - Free Radical Biology and Medicine, 2018 - Elsevier
Selenium has transitioned from an environmental poison and carcinogen to an essential
micronutrient associated with a broad array of health promoting effects. These beneficial …

Molecular mechanisms of cancer prevention by selenium compounds

J Fleming, A Ghose, PR Harrison - Nutrition and Cancer, 2001 - Taylor & Francis
Selenium compounds that are chemopreventive in animal models inhibit cell growth and
induce apoptosis in vitro, and this could explain how they reduce the outgrowth of tumor …

The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities

Z Huang, AH Rose, PR Hoffmann - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Dietary selenium (] Se), mainly through its incorporation into selenoproteins, plays
an important role in inflammation and immunity. Adequate levels of Se are important for …

Selenoproteins and their role in oxidative stress and inflammation

UH Gandhi, TP Nagaraja… - Current chemical …, 2013 - ingentaconnect.com
The discovery of selenocysteine as the 21st amino acid has revolutionized the
understanding of the significance of the essential micronutrient selenium in human and …

Selenium and the regulation of cell signaling, growth, and survival: molecular and mechanistic aspects

RC McKenzie, JR Arthur, GJ Beckett - Antioxidants and Redox …, 2002 - liebertpub.com
In the past 30 years, it has been recognized that dietary selenium (Se) is essential for the
normal function of many of the systems of the body. Furthermore, low Se intake can have …

xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers

N Lee, AE Carlisle, A Peppers, SJ Park, MB Doshi… - Antioxidants, 2021 - mdpi.com
Inducers of ferroptosis such as the glutathione depleting agent Erastin and the GPX4
inhibitor Rsl-3 are being actively explored as potential therapeutics in various cancers, but …

Selenium and selenoproteins: It's role in regulation of inflammation

S Hariharan, S Dharmaraj - Inflammopharmacology, 2020 - Springer
Selenium is an essential immunonutrient which holds the human's metabolic activity with its
chemical bonds. The organic forms of selenium naturally present in human body are …