Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis
is now defined as life-threatening organ dysfunction caused by a dysregulated host …

Purpose Sepsis is a clinical syndrome defined as life-threatening organ dysfunction caused
by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome …

Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host
response to infection characterized by excessive neutrophil infiltration into vital organs. In …

Sepsis is a life-threatening condition caused by a dysregulated host response to infection.
Despite continued efforts to understand the pathophysiology of sepsis, no effective therapies …

During sepsis, defined as life-threatening organ dysfunction due to dysregulated host
response to infection, systemic inflammation activates endothelial cells and initiates a …

Sepsis is a major health issue and a leading cause of death in hospitals globally. The
treatment of sepsis is largely supportive, and there are no therapeutics available that target …

Sepsis is a major health problem worldwide. It is a time-dependent disease, with a high rate
of morbidity and mortality. In this sense, an early diagnosis is essential to reduce these rates …

In the last decades, it has become evident that endothelial cells (ECs) in the
microvasculature play an important role in the pathophysiology of sepsis-associated multiple …

A key aspect of cytokine-induced changes as observed in sepsis is the dysregulated
activation of endothelial cells (ECs), initiating a cascade of inflammatory signaling leading to …

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …