Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …

Five parallel anatomic circuits link regions of the frontal cortex to the striatum, globus
pallidus/substantia nigra, and thalamus. The circuits originate in the supplementary motor …

Mood disorders cause significant morbidity and mortality, and existing therapies fail 20%–
30% of patients. Deep brain stimulation (DBS) is an emerging treatment for refractory mood …

Significant interest in the mechanistic underpinnings of obsessive-compulsive disorder
(OCD) has fueled research on the neural origins of compulsive behaviors. Converging …

Obsessive-compulsive disorder (OCD) is a disabling illness with high rates of nonresponse
to conventional treatments. OCD pathophysiology is believed to involve abnormalities in …

Frontal circuits play a critical role in motor, cognitive and affective processing, and their
dysfunction may result in a variety of brain disorders. However, exactly which frontal …

Contemporary research on the links between brain, mind, and human behavior has
revealed the key role of the frontal-subcortical circuits in a wide range of neuropsychiatric …

Background. Impaired emotion regulation may underlie exaggerated emotional reactivity in
patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has …

Background Decision-making and impulse control (both cognitive and motor) are complex
interrelated processes which rely on a distributed neural network that includes multiple …