Intrinsic obstacles to human immunodeficiency virus type 1 coreceptor switching
C Pastore, A Ramos, DE Mosier - Journal of virology, 2004 - Am Soc Microbiol
The natural evolution of human immunodeficiency virus type 1 infection often includes a
switch in coreceptor preference late in infection from CCR5 to CXCR4, a change associated …
switch in coreceptor preference late in infection from CCR5 to CXCR4, a change associated …
Evolution of CCR5 use before and during coreceptor switching
M Coetzer, R Nedellec, J Salkowitz… - Journal of …, 2008 - Am Soc Microbiol
The envelope gene (env) of human immunodeficiency virus type 1 (HIV-1) undergoes rapid
divergence from the transmitted sequence and increasing diversification during the …
divergence from the transmitted sequence and increasing diversification during the …
Conserved changes in envelope function during human immunodeficiency virus type 1 coreceptor switching
C Pastore, R Nedellec, A Ramos, O Hartley… - Journal of …, 2007 - Am Soc Microbiol
We studied the evolution of human immunodeficiency virus type 1 (HIV-1) envelope function
during the process of coreceptor switching from CCR5 to CXCR4. Site-directed mutagenesis …
during the process of coreceptor switching from CCR5 to CXCR4. Site-directed mutagenesis …
Human immunodeficiency virus type 1 coreceptor switching: V1/V2 gain-of-fitness mutations compensate for V3 loss-of-fitness mutations
C Pastore, R Nedellec, A Ramos, S Pontow… - Journal of …, 2006 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) entry into target cells is mediated by the virus
envelope binding to CD4 and the conformationally altered envelope subsequently binding …
envelope binding to CD4 and the conformationally altered envelope subsequently binding …
HIV-1 escape to CCR5 coreceptor antagonism through selection of CXCR4-using variants in vitro
G Moncunill, M Armand-Ugón, E Pauls, B Clotet… - Aids, 2008 - journals.lww.com
Background: HIV-1 coreceptor switch from CCR5 to CXCR4 is associated with disease
progression and AIDS. Selection of resistant HIV-1 to CCR5 agents in cell culture has often …
progression and AIDS. Selection of resistant HIV-1 to CCR5 agents in cell culture has often …
The HIV coreceptor switch: a population dynamical perspective
RR Regoes, S Bonhoeffer - Trends in microbiology, 2005 - cell.com
Over the course of infection, the coreceptor usage of the HIV virus changes from a
preference for CCR5 to a preference for CXCR4 in∼ 50% of infected individuals. The …
preference for CCR5 to a preference for CXCR4 in∼ 50% of infected individuals. The …
R5X4 viruses are evolutionary, functional, and antigenic intermediates in the pathway of a simian-human immunodeficiency virus coreceptor switch
S Tasca, SH Ho, C Cheng-Mayer - Journal of virology, 2008 - Am Soc Microbiol
To examine the pathway of the coreceptor switching of CCR5-using (R5) virus to CXCR4-
using (X4) virus in simian-human immunodeficiency virus SHIVSF162P3N-infected rhesus …
using (X4) virus in simian-human immunodeficiency virus SHIVSF162P3N-infected rhesus …
Differences in molecular evolution between switch (R5 to R5X4/X4-tropic) and non-switch (R5-tropic only) HIV-1 populations during infection
M Mild, A Kvist, J Esbjörnsson, I Karlsson… - Infection, Genetics and …, 2010 - Elsevier
The recent introduction of entry inhibitors in the clinic as components of antiretroviral
treatment has heightened the interest in coreceptor use of human immunodeficiency virus …
treatment has heightened the interest in coreceptor use of human immunodeficiency virus …
Frequent intrapatient recombination between human immunodeficiency virus type 1 R5 and X4 envelopes: implications for coreceptor switch
M Mild, J Esbjornsson, EM Fenyo… - Journal of …, 2007 - Am Soc Microbiol
Emergence of human immunodeficiency virus type 1 (HIV-1) populations that switch or
broaden coreceptor usage from CCR5 to CXCR4 is intimately coupled to CD4+ cell …
broaden coreceptor usage from CCR5 to CXCR4 is intimately coupled to CD4+ cell …
Coevolution of RANTES sensitivity and mode of CCR5 receptor use by human immunodeficiency virus type 1 of the R5 phenotype
I Karlsson, L Antonsson, Y Shi, M Oberg… - Journal of …, 2004 - Am Soc Microbiol
The evolution of human immunodeficiency virus type 1 (HIV-1) coreceptor use has been
described as the acquisition of CXCR4 use linked to accelerated disease progression …
described as the acquisition of CXCR4 use linked to accelerated disease progression …