Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms

ÖD Can, ÜD Özkay, Uİ Üçel - European journal of pharmacology, 2013 - Elsevier
The present study was designed to investigate the putative effect of vitexin, a flavone C–
glucoside present in some drugs, medicinal plants and nutraceuticals, on the central …

Vitexin possesses anticonvulsant and anxiolytic-like effects in murine animal models

DD De Oliveira, CP Da Silva, BB Iglesias… - Frontiers in …, 2020 - frontiersin.org
Different types of epilepsy and forms of pathological anxiety have been described as
significant neurological disorders that may exist as comorbidities. Some of those disorders …

Anti-nociceptive effect of vitexin mediated by the opioid system in mice

ÜD Özkay, ÖD Can - Pharmacology Biochemistry and Behavior, 2013 - Elsevier
In the present study, we determined the potential anti-nociceptive activity of vitexin, a C-
glycosylated flavone, by conducting some acute nociceptive tests in mice. Centrally …

[HTML][HTML] Beneficial role of Vitexin in Parkinson's disease

M Mustapha, CNM Taib - The Malaysian journal of medical …, 2023 - ncbi.nlm.nih.gov
Today, Parkinson's disease (PD) is the foremost neurological disorder all across the globe.
In the quest for a novel therapeutic agent for PD with a multimodal mechanism of action and …

[PDF][PDF] General pharmacology of Vitex leucoxylon Linn leaves

HG Makwana, B Ravishankar, VJ Shukla… - Indian Journal of …, 1994 - ijpp.com
Ethanol extract (ETE) and cold aqueous infusion (CAl) of Vitex leueoxylon leaf were
evaluated in a battery of tests to define the activity profile of the plan\. CAl dcpressed SMA …

Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons

L Yang, Z Yang, N Zhang, Z Tian, S Liu… - Molecular and cellular …, 2014 - Springer
The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA)
receptors and cause excitotoxicity. Vitexin (5, 7, 4-trihydroxyflavone-8-glucoside, Vit) is a c …

Anxiolytic activity of Vitex negundo Linn. in experimental models of anxiety in mice

RS Adnaik, PT Pai, VD Sapakal… - … Journal of Green …, 2009 - greenpharmacy.info
The purpose of this study was to characterize the putative anxiolytic-like activity of an
ethanolic extract prepared from the roots of Vitex negundo (VN) using the elevated plus …

A brief review on the neuroprotective mechanisms of vitexin

LKF Lima, SKS Pereira, RSS Junior… - BioMed Research …, 2018 - Wiley Online Library
The neural dysfunction is triggered by cellular and molecular events that provoke
neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly …

Hepatic, gastric, and intestinal first-pass effects of vitexin in rats

HF Xue, ZM Ying, WJ Zhang, YH Meng… - Pharmaceutical …, 2014 - Taylor & Francis
Context: Recent research has demonstrated that vitexin exhibits a prominent first-pass effect.
In this light, it is necessary to investigate the causes of this distinct first-pass effect. Objective …

Antitussive and toxicological evaluation of Vitex negundo

R Haq, AHA Shah, A Khan, Z Ullah, H Khan… - Natural Product …, 2012 - Taylor & Francis
Vitex negundo Linn.(Verbenaceae) is used in traditional medical system for respiratory
disorders. This study was carried out to investigate its cough-relieving potential. The …