Purpose: Microarray studies indicate medulloblastoma comprises distinct molecular disease
subgroups, which offer potential for improved clinical management. Experimental Design …

Medulloblastoma is heterogeneous, being characterized by molecular subgroups that
demonstrate distinct gene expression profiles. Activation of the WNT or SHH signaling …

Embryonal brain tumors are a heterogeneous group of neoplasms united by the presence of
poorly differentiated stem‐like cells. Molecular details are increasingly being used to …

Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine …

Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor.
Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three …

Medulloblastoma is the most common malignant brain tumor in childhood. Molecular studies
from several groups around the world demonstrated that medulloblastoma is not one …

A recent analysis of the genetic features of medulloblastoma (MB) suggested classification
into distinct subgroups according to gene expression profiles, including the Wingless …

Rapidly evolving genomic technologies have permitted progressively detailed studies of
medulloblastoma biology in recent years. These data have increased our understanding of …

Purpose Traditional genetic approaches to identify gene mutations in cancer are expensive
and laborious. Nonetheless, if we are to avoid rejecting effective molecular targeted …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently
diagnosed and stratified using a combination of clinical and demographic variables. Recent …