Background: Recent studies hint at mitochondrial genes influencing UC patient response to
anti-TNF treatment. We evaluated this hypothesis by following a targeted strategy to identify …

Molecular mechanisms driving disease course and response to therapy in ulcerative colitis
(UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene …

Anti-TNF therapy can induce and maintain a remission status during intestinal bowel
disease. However, up to 30% of patients do not respond to this therapy by mechanisms that …

Background Accumulating evidence reveals mitochondrial dysfunction exacerbates
intestinal barrier dysfunction and inflammation. Despite the growing knowledge of …

Ulcerative colitis (UC) is a complex, multifactorial disease driven by a dysregulated immune
response against host commensal microbes. Despite rapid advances in our understanding …

Background Inflammatory Bowel Disease (IBD) involves an interplay of gut microbiota,
intestinal epithelium and immune responses. Recent data suggest that decreased …

Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial
components and reduced mitochondrial ATP production; however, synergism between both …

Ulcerative colitis (UC) is a chronic inflammatory disorder primarily affecting the colon
mucosa. Its etiology and pathogenesis remain unclear. We used 2‐DE and MS to identify …

Inflammatory bowel disease (IBD) is a complex, chronic, relapsing and heterogeneous
disease induced by environmental, genomic, microbial and immunological factors. MCJ is a …

Abstract Background Long non-coding RNAs (lncRNAs) are tissue-specific and regulate
cellular functions. We previously reported a dramatic inhibition of epithelial metabolic …