Spinal cord injuries impose a notably economic burden on society, mainly because of the
severe after-effects they cause. Despite the ongoing development of various therapies for …

Neural tissue has high metabolic requirements. Following spinal cord injury (SCI), the
damaged tissue suffers from a severe metabolic impairment, which aggravates axonal …

Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding
process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons …

After central nervous system (CNS) injury, severed axons fail to regenerate and their
disconnections to the original targets result in permanent functional deficits in patients …

Mitochondrial dysfunction occurs in the early stage of axonal degeneration after spinal cord
injury and involves oxidative stress, energy deficiency, imbalance of mitochondrial …

Traumatic spinal cord injuries interrupt the connection of all axonal projections with their
neuronal targets below and above the lesion site. This interruption results in either …

Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Axons in the mature central nervous system (CNS) fail to regenerate after axotomy, partly
due to the inhibitory environment constituted by reactive glial cells producing astrocytic …

Chronic spinal cord injury (SCI) is associated with the development of serious medical
concerns. In fact, it is increasingly well documented that most SCI patients who survive the …

Spinal cord injury (SCI) is an irreversible condition causing damage to myelinated fiber
tracts that carry sensation and motor signals to and from the brain. SCI is also associated …