Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

The biological effects of the steroid hormone, estradiol, are largely mediated by estrogen
receptor (ER) proteins within the nuclei of target cells. The ER protein exists in two known …

The biological effects of estrogen (E) in mammalian target tissues are important for
numerous physiological processes. E is known to induce responses in the reproductive tract …

In addition to their well known control of reproductive functions, estrogens modulate
important physiological processes. The identification of compounds with tissue-selective …

I. Introduction T HE idea to write this review began a number of years ago when one of us
(DRC) was working in Dr. William L. McGuire's laboratory in San Antonio, Texas, 1 where we …

Three aspects of recent development in estrogen receptor research will be discussed in this
review. First, since the discovery of the second estrogen receptor, ERβ, a new era has …

Antiestrogens are known to interact with the estrogen receptor system of target cells. In
addition, it is possible that recently identified estrogen-noncompetable, antiestrogenspecific …

Estradiol-17β (E2) stimulates uterine and vaginal epithelial proliferation in vivo [1]. E2 also
plays a critical role in other aspects of uterine and vaginal growth and adult function, and it is …

We have previously shown that neonatal exposure of rats to pharmacologic doses of
diethylstilbestrol via daily injections resulted in a significant decrease in the estrogen …

Nineteen years have passed since our previous review in this journal in 1999 regarding
estrogen receptors. At that time, we described the current assessments of the physiological …