Information on regional variation in cell numbers and densities in the CNS provides critical
insight into structure, function, and the progression of CNS diseases. However, variability …

Stereological methods for tissue cell counting, specifically for neuron quantification,
decrease systematic error and sampling bias; however, they are tedious, labor intensive …

Cells are not uniformly distributed in the human cerebral cortex. Rather, they are arranged in
a regional and laminar fashion that span a range of scales. Here we demonstrate an …

Aims In brain research, the histopathological examination of coronar whole-brain slides
provides important insights into spatial disease characteristics. Regarding brain tumor …

A new framework for measuring densities of immunolabeled neurons across cortical layers
was implemented that combines a confocal microscopy sampling strategy with automated …

The process through which neurons are labeled is a key methodological choice in
measuring neuron morphology. However little is known about how this choice may bias …

Motivation From image stacks to computational models, processing digital representations of
neuronal morphologies is essential to neuroscientific research. Workflows involve various …

The advent of three-dimensional histological methods has advanced studies of cellular-
resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has …

Recent advances in brain imaging allow producing large amounts of 3-D volumetric data
from which morphometry data is reconstructed and measured. Fine detailed structural …

Measurement of neuronal size is challenging due to their complex histology. Current
practice includes manual or pseudo-manual measurement of somatic areas, which is labor …