INTRODUCTION Members of the human gut microbiota have been implicated in the
development and progression of colorectal cancer (CRC). These CRC-associated …

INTRODUCTION Research on the human microbiome has revealed extensive correlations
between bacterial populations and host physiology and disease states. However, moving …

Colibactin is a secondary metabolite encoded by the pks gene island identified in several
Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly …

The mucosal epithelium is a common target of damage by chronic bacterial infections and
the accompanying toxins, and most cancers originate from this tissue. We investigated …

Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli,
Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island …

The gut microbiota is suspected to promote colorectal cancer (CRC). Escherichia coli are
more frequently found in CCR biopsies than in healthy mucosa; furthermore, the majority of …

Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the
clb genomic island that has a widespread distribution in pathogenic and commensal human …

The human gut bacterial genotoxin colibactin is a possible key driver of colorectal cancer
(CRC) development. Understanding colibactin's biological effects remains difficult owing to …

Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin
causes DNA damage that may lead to colorectal cancer. Here we review recent advances in …

Genotoxic colibactin-producing pks+ Escherichia coli induce DNA double-strand breaks,
mutations, and promote tumor development in mouse models of colorectal cancer (CRC) …